Studies on epidemiology and transmission mechanisms of lymphocytic choriomeningitis virus in Japan.

日本淋巴细胞性脉络膜脑膜炎病毒流行病学及传播机制研究。

• 批准号: 04660338
• 负责人: MORITA Chiharu
• 金额: $ 1.6万
• 依托单位: Rakuno-Gakuen University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1992
• 资助国家: 日本
• 起止时间: 1992 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-04660338/
• 关键词: lymphocytic choriomeningitis virus; LCMV; wild house mouse; Mus musculus; subspecies; epidemiology; リンパ球性脈絡髄膜炎; 水平伝播; LCM; 東南アジア; Mus musculus castaneus

Recently, we reported occurrence of antibodies and isolation of lymphocytic choriomeningitis virus (LCMV) in two international ports in Japan. Attempts to detect the antibody or the virus in any other place in Japan have not succeeded until now. We utilized genetic analysis of ribosomal DNA and mitochondrial DNA to detect subspecies of Mus.musculus in some areas including LCMV-positive ports in Japan. As the results, M.m.castaneus was assumed to be the carrier reservoir of the virus invading to Japan. There is no report detecting LCMV in the habitat area of M.m.castaneus. The survey of 6 countries including China revealed LCMV existed in M.m.castaneus. In addition, the antibodies against LCMV were revealed in the mice captured in the northern part of China where was the habitat of M.m.gansuensis. LCMV is thought to be maintained by vertical transmission from dams to their offsprings. We analyzed matrilineal linage of mice captured in Osaka Port. Horizontal transmission of the virus has an important role to maintain the virus in the population of the wild house mouse.

最近，我们报道了日本两个国际港口出现抗体并分离出淋巴细胞性脉络膜脑膜炎病毒（LCMV）。迄今为止，在日本其他地方检测抗体或病毒的尝试尚未成功。我们利用核糖体 DNA 和线粒体 DNA 的遗传分析来检测包括日本 LCMV 阳性港口在内的一些地区的小家鼠亚种。结果，M.m.castaneus被认为是入侵日本的病毒的携带者。目前尚无栗鳉栖息地发现 LCMV 的报道。对中国等6个国家的调查显示栗鳉中存在LCMV。此外，在中国北部地区甘肃疟原虫的栖息地捕获的小鼠中也发现了针对LCMV的抗体。 LCMV被认为是通过从母体到其后代的垂直传播来维持的。我们分析了在大阪港捕获的小鼠的母系谱系。病毒的水平传播对于野家鼠种群中病毒的维持具有重要作用。

项目成果

C,Morita,H.Suzuki,T.Tanikawa et al: "Origin of Lymphocytic Choriomeningitis Virus Bearing Mice in Japan." J,Vet,Med.,. B-41. 291-293 (1994)

C，Morita，H.Suzuki，T.Tanikawa 等：“日本携带淋巴细胞脉络丛脑膜炎病毒的小鼠的起源”。

C,Morita,H.Ueno,H.Suzuki: "Did lynphocytic choriomeningitis virus bearing mice invade into Japan from South Asian counrries?" Proc.The 11th International Symposium of WAVFA October,1993 Bangkok,Thailand. 136-138 (1993)

C、Morita、H.Ueno、H.Suzuki：“携带淋巴细胞脉络膜脑膜炎病毒的小鼠是否从南亚国家入侵日本？”

C,Morita, H.Suzuki, T.Tanikawa, T.Yabe, J.Eda, H.Hirukawa, H.Ueno and M.Chenchittikul: "Origin of Lymphocytic Choriomeningitis Virus Bearing Mice in Japan." J.Vet.Med.B-41. 291-293 (1994)

C、Morita、H.Suzuki、T.Tanikawa、T.Yabe、J.Eda、H.Hirukawa、H.Ueno 和 M.Chenchittikul：“日本携带淋巴细胞脉络丛脑膜炎病毒的小鼠的起源”。

C.Morita,H.Ueno and H.Suzuki: "Did lymphocytic choriomeningitis virus bearing mice invade into Japan from south Asian counries" Proc.11th inter Symp WAVFA. 136-138 (1993)

C.Morita、H.Ueno 和 H.Suzuki：“携带淋巴细胞性脉络丛脑膜炎病毒的小鼠是否从南亚国家入侵日本”Proc.11th inter Symp WAVFA。

C.Morita, H.Ueno and H.Suzuki: "Did lymphocytic choriomeningitis virus bearing mice invade into Japan from South Asian counrries?" Proc.The 11th International Symposium of WAVFA.136-138 (1993)

C.Morita、H.Ueno 和 H.Suzuki：“携带淋巴细胞性脉络膜脑膜炎病毒的小鼠是否从南亚国家入侵日本？”