Studies on epidemiology and transmission mechanisms of lymphocytic choriomeningitis virus in Japan.

最近，我们报告了在日本的两个国际港口发生的抗体和淋巴细胞性脉络丛脑膜炎病毒（LCMV）的分离。到目前为止，在日本任何其他地方检测抗体或病毒的尝试都没有成功。我们利用核糖体DNA和线粒体DNA的遗传分析，以检测亚种小家鼠在一些地区，包括在日本的LCMV阳性港口。因此，推测栗粒小球藻是入侵日本的病毒的携带者。在栗树根结线虫的生境中尚未发现LCMV的报道。包括中国在内的6个国家的调查结果表明，栗粒小孢子虫（M.m.castaneus）存在LCMV。另外，在甘肃省北方地区采集的小鼠中也发现了抗LCMV的抗体。LCMV被认为是通过从母鼠到其后代的垂直传播来维持的。我们分析了在大坂港捕获的小鼠的母系血统。病毒的水平传播对维持病毒在野生家鼠种群中的存在具有重要作用。

Recently, we reported occurrence of antibodies and isolation of lymphocytic choriomeningitis virus (LCMV) in two international ports in Japan. Attempts to detect the antibody or the virus in any other place in Japan have not succeeded until now. We utilized genetic analysis of ribosomal DNA and mitochondrial DNA to detect subspecies of Mus.musculus in some areas including LCMV-positive ports in Japan. As the results, M.m.castaneus was assumed to be the carrier reservoir of the virus invading to Japan. There is no report detecting LCMV in the habitat area of M.m.castaneus. The survey of 6 countries including China revealed LCMV existed in M.m.castaneus. In addition, the antibodies against LCMV were revealed in the mice captured in the northern part of China where was the habitat of M.m.gansuensis. LCMV is thought to be maintained by vertical transmission from dams to their offsprings. We analyzed matrilineal linage of mice captured in Osaka Port. Horizontal transmission of the virus has an important role to maintain the virus in the population of the wild house mouse.