Mononuclear Phagocyte System In Relation To The Development Of Hemopoietic Tissue Of The Mouse Embryo-Light And Electron Microscopic Studies
单核吞噬细胞系统与小鼠胚胎造血组织发育的关系光和电子显微镜研究
基本信息
- 批准号:04670029
- 负责人:
- 金额:$ 1.28万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for General Scientific Research (C)
- 财政年份:1992
- 资助国家:日本
- 起止时间:1992 至 1993
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Blood And Coelom Mononuclear Phagocytes Before Liver Hemopioesis : Circulating blood cells of a 10-day fetal mouse are primtive erythroblasts derived from yolk sac blood islands, and many mononuclear cells appar in the periphral blood. Free phagocytes with similar ultrastructural features also can be observed in intraembryonic peritoneal cavities, and the precursors of these phagocytes are not monocytes but mononuclear cells from yolk sac or mesenchyme.Scavenger Macrohages in Fetal Liver : Livers of 12-day mouse embryos contain macrophages laden with large heterophagosomes in sinusoids. Macrophages, as scavengers, engulf circulationg primitive erythroblasts from the yolk sac as well as nuclei expelled from erythroblasts. Scavenger macrophages are seen in mitosis to migrate from sinusoids into hepatic cords, forming cell clusters designated as erythroblastic islets. Blood mononuclear cells are considered to be the precursors of the hepatic macrophages.Thymus Macrophages : Monocytes as w … More ell as macrohages laden with phagocytic inclusions first appear in the perivascular space or very close to blood vessels at the cortico-medullary junction of the 15-day-embryo thymus. The perivascular spaces contain many monocyte-like cells, and candidates of precursors of thymic macrophages are monocytes probably from the fetal liver.Phagocytes In Fetal Spleen And Neonatal Bone Marrow : Spleen in fetal and early postnatal mice contains two kinds of phagocytes, scavenger macrophages and mast cells, and their phagocytotic activity is directed toward extruded erythrocytic nuclei, erythrocytes and dying hemopoietic cells. Neonatal femoral marrow cavity contains many polymorph nuclear leucocyte, showing early signs of cell degeneration. Not only free macrophages but fixed reticular cells engulf and digest apoptotic neutrophils in the hemopoietic compartment of bone marrow. The orign of spleen and bone marrow scavengers should be considered in relation to monocyte producion in the fetal liver. Less
肝出血前的血液和体腔单核巨噬细胞:10日龄胎鼠的循环血细胞是来源于卵黄囊血岛的原始红细胞,外周血中可见许多单核细胞。胚胎腹膜腔内也可观察到具有相似超微结构的游离吞噬细胞,其前体细胞不是单核细胞,而是来自卵黄囊或间充质的单核细胞。胎肝清道夫巨噬细胞:12日龄小鼠胚胎肝脏中含有巨噬细胞,内含大的异噬菌体,呈血窦状。巨噬细胞作为清道夫,吞噬来自卵黄囊的原始红细胞和从红细胞中排出的核。清道夫巨噬细胞在有丝分裂中从肝窦迁移到肝索,形成细胞团,命名为红母细胞胰岛。血液中的单个核细胞被认为是肝巨噬细胞的前体。胸腺巨噬细胞:单核细胞与w…在15日龄胚胎胸腺的皮质-髓质交界处,更多的巨噬细胞首先出现在血管周围或非常靠近血管的地方,其中含有吞噬包涵体的细胞最多。胎脾和新生儿骨髓中的吞噬细胞:胎鼠和出生早期小鼠的脾含有两种吞噬细胞:清道夫巨噬细胞和肥大细胞,它们的吞噬活性指向突出的红核、红细胞和死亡的造血细胞。新生儿股骨骨髓腔内含有大量多形性核白细胞,表现为早期细胞变性迹象。不仅是游离的巨噬细胞,而且固定的网状细胞吞噬和消化骨髓造血室中的凋亡的中性粒细胞。脾和骨髓清道夫的起源应该与胎肝中单核细胞的产生有关。较少
项目成果
期刊论文数量(46)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
佐々木和信: "マウス骨髄造血の発生と好中球の細胞死:HPMA切片による光学ならびに電子顕微鏡観察" 解剖学雑誌. 68. 687 (1993)
Kazunobu Sasaki:“小鼠骨髓造血和中性粒细胞死亡的发展:使用 HPMA 切片进行光学和电子显微镜观察”《解剖学杂志》68. 687 (1993)。
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Sasaki K.Iwatsuki H.Suda M.& Itano C.: "Cell Death and Phagocytosis of Haemopoietic Elements at the Onset of Haemopoiesis in the Mouse Spleen : An Ultrastructural Study" Journal of Anatomy. 183. 113-120 (1993)
佐佐木 K.岩槻 H.须田 M.
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Sasaki K.: "Appearance of monocytes and macrophages in the embryonic thymus of the mouse: light and electron microscopic studies." Acta Anat Nippon. 67. 28-37 (1992)
Sasaki K.:“小鼠胚胎胸腺中单核细胞和巨噬细胞的外观:光和电子显微镜研究。”
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- 影响因子:0
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- 通讯作者:
Sasaki K.: "Scavenger macrophages and central macrophages of erythroblastic islands in liver hemopoiesis of fetal and early postnatal mouse" Acta Anatomica. (1993)
Sasaki K.:“胎儿和产后早期小鼠肝脏造血中红细胞岛的清道夫巨噬细胞和中央巨噬细胞”《解剖学报》。
- DOI:
- 发表时间:
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- 影响因子:0
- 作者:
- 通讯作者:
Sasaki K.: "Cell death and phagocytosis of haemopoietic elements at the onset of haemopoiesis in the mouse spleen:an ultrastructural study." Journal of Anatomy. 183. 113-120 (1993)
Sasaki K.:“小鼠脾脏造血开始时的细胞死亡和造血元素的吞噬作用:一项超微结构研究。”
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SASAKI Kazunobu其他文献
SASAKI Kazunobu的其他文献
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{{ truncateString('SASAKI Kazunobu', 18)}}的其他基金
Liver cell rearrangement and apoptosis duirng retardation of fetal hematopoiesis
胎儿造血迟缓期间的肝细胞重排和凋亡
- 批准号:
14570031 - 财政年份:2002
- 资助金额:
$ 1.28万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Liver hematopoiesis and hematopoietic microenvironment - three dimensional reconstruction and immunohistochemical observation of CD markers
肝脏造血及造血微环境——CD标记物的三维重建及免疫组化观察
- 批准号:
12670033 - 财政年份:2000
- 资助金额:
$ 1.28万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Ultrastructural and ultracytochemical observations on differentiation and fate of liver macrophages of the mouse embryo
小鼠胚胎肝巨噬细胞分化和命运的超微结构和超细胞化学观察
- 批准号:
07670043 - 财政年份:1995
- 资助金额:
$ 1.28万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Cytometrical analysis of blood monocytes : comparative studies of adult peripheral blood and embryonic hemopoietic organs.
血液单核细胞的细胞计数分析:成人外周血和胚胎造血器官的比较研究。
- 批准号:
02670001 - 财政年份:1990
- 资助金额:
$ 1.28万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)
Qualitative and cytometrical observations of mononuclear cells in the intraembryonic coelom of mouse embryo.
小鼠胚胎胚内体腔中单核细胞的定性和细胞计数观察。
- 批准号:
63570001 - 财政年份:1988
- 资助金额:
$ 1.28万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)
The development of the embryonic hemopoietic organs from yolk sac to liver and spleen: a cytometrical observation.
胚胎造血器官从卵黄囊到肝脏和脾脏的发育:细胞计数观察。
- 批准号:
61570001 - 财政年份:1986
- 资助金额:
$ 1.28万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)
相似海外基金
Yolk Sac MicroRNAs Regulate Brain Development
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- 批准号:
10750884 - 财政年份:2023
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$ 1.28万 - 项目类别:
Understand the contribution of yolk sac-derived macrophage progenitors to the generation of adipose tissue macrophages and the development of insulin resistance
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$ 1.28万 - 项目类别:
Research Grants
Use of the Yolk Sac to Decipher the Molecular Requirements for Liver Bud Development
利用卵黄囊破译肝芽发育的分子要求
- 批准号:
9113580 - 财政年份:2015
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$ 1.28万 - 项目类别:
Use of the Yolk Sac to Decipher the Molecular Requirements for Liver Bud Development
利用卵黄囊破译肝芽发育的分子要求
- 批准号:
8969166 - 财政年份:2015
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$ 1.28万 - 项目类别:
Lymphopoietic development in the extra-embryonic yolk sac
胚胎外卵黄囊的淋巴细胞发育
- 批准号:
7994151 - 财政年份:2008
- 资助金额:
$ 1.28万 - 项目类别:
Lymphopoietic development in the extra-embryonic yolk sac
胚胎外卵黄囊的淋巴细胞发育
- 批准号:
7751826 - 财政年份:2008
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$ 1.28万 - 项目类别:
Lymphopoietic development in the extra-embryonic yolk sac
胚胎外卵黄囊的淋巴细胞发育
- 批准号:
7565153 - 财政年份:2008
- 资助金额:
$ 1.28万 - 项目类别:
Lymphopoietic development in the extra-embryonic yolk sac
胚胎外卵黄囊的淋巴细胞发育
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8389561 - 财政年份:2008
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$ 1.28万 - 项目类别: