权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Clinicopathologic and biologic study of the neoplasms arising from the T-cell area of the lymph node.

淋巴结 T 细胞区域肿瘤的临床病理学和生物学研究。

基本信息

批准号：
04670196
负责人：
NAKAMURA Shigeo
金额：
$ 1.22万
依托单位：
Aichi Cancer Center Research Institute
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1992
资助国家：
日本
起止时间：
1992 至 1993
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-04670196/
关键词：
Lymph node T-cell area Neoplasm Clinicopathology Biology Peripheral T-cell lymphoma Dendritic cell tumor Lymph node T-zone Interdigitating cell Neoplasm Peripheral T-cell lymphoma Phenotype Genotype CD56

项目摘要

In the present study, we investigated the tumor arsing from the T-cell area of the lymph node. Peripheral T-cell lymphoma (PTCL) was classified according to the updated Kiel (Suchi) classification. The clinicopathologic, phenotypic and genotypic findings of node-based, low-grade, PTCL (AILD type, T-zone type, and lymphoepithelioid type) were summarized (Cancer 1991 ; 67 : 2565). The proportion of the neoplastic cells (CD4+, Ki67+) in these tumors was demonstrated to have a relatively good correlation with the clonal TCRbeta rearrangement (Cancer 1993 ; 72 : 1762, Acta Pathol Jpn 1993 ; 43 : 396). In the process of the (Cancer 1993 ; 71 : 249). An accumulation of the additional 10 cases of this tumor suggested them to constitue a unique subgroup regarded as high-grade lymphoma, although some might be of natural killer (NK) cell lineage.Interdigitating cell sarcoma was an extremely rare tumor arising from the paracortical area in the lymph node (Cancer 1988 ; 61 : 562). Recently, we described the histologic and immunophenotypic features of four cases of this tumor (Pathol Int 1994 ; in press).We are going to examine the participation of oncogene and antioncogene in those tumors.

在本研究中，我们研究了起源于淋巴结t细胞区域的肿瘤。外周t细胞淋巴瘤（PTCL）根据更新的Kiel （Suchi）分类进行分类。总结了以淋巴结为基础的低级别PTCL （AILD型、t区型和淋巴上皮样型）的临床病理、表型和基因型发现（Cancer 1991; 67: 2565）。肿瘤细胞（CD4+, Ki67+）在这些肿瘤中的比例与克隆TCRbeta重排有较好的相关性（Cancer 1993; 72: 1762; Acta Pathol Jpn 1993; 43: 396）。（巨蟹座1993；71:249）。另外10例肿瘤的累积表明，它们构成了一个独特的亚组，被认为是高级别淋巴瘤，尽管有些可能是自然杀伤（NK）细胞谱系。间指细胞肉瘤是一种极其罕见的肿瘤，起源于淋巴结皮质旁区（Cancer 1988; 61: 562）。最近，我们描述了4例这种肿瘤的组织学和免疫表型特征（病理学Int 1994； in press）。我们将研究癌基因和反基因在这些肿瘤中的作用。