Clinicopathologic and molecular biologic study of borderline lymphoproliferative disorders

交界性淋巴增殖性疾病的临床病理学和分子生物学研究

• 批准号: 08670234
• 负责人: NAKAMURA Shigeo
• 金额: $ 1.6万
• 依托单位: Aichi Cancer Center
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08670234/
• 关键词: Borderline lesion; Malignant lymphoma; Epstein-Barr virus; Pathology; Molecular biology; Prognosis; 予後; 臨床病理学; 胚中心進展性異形成; T領域異形成; 染色体転座関連遺伝子; 癌関連遺伝子

Malignant lympomas and its related lymphoproliferative disorders reveal the broad clinicopathologic, biologic and endemic spectrum. In several recent years, much interest is focused on the borderline lesions, e.g., T-zone dysplasia, progressive transformation of germinal center, and Epstein-Barr virus (EBV) - or autoimmunerelated lesions frequently encountered in the immunocompremised hosts and elderly patients. The aim of the present study was to recognize the disease spectrum laying between these borderline lesions and malignant lymphomas. A previously undescribed type of EBV-associated lymphoprliferative disorder featured by the rapid pregression of the disease has been identified in the present study (manuscipt in contribution). In these cases, monoclonal integration of EBV genome was domenstrated. However, it was currently unclear whether they were bona fide neoplasms or reactive lesions, suggesting the difficulty in their distinction from the pathologic and biologic viewpoints. On the other hand, several cases, which were currently ill-defined and tentatively diagnosed as borderline lesions without evidence of the clonal preliferation of any cells, has been encountered in the elderly patients. These cases persued the indolent clinical course over the time of the present study, and their clinicopathologic and biologic nature remains to be elucidated. The present data suggest that the borderline lymphoproliferative disorders might be regarded as the desintegration of the immunesystem more or less induced by pathologic agents. Futher investigtion is needed.

恶性淋巴瘤及其相关淋巴增生性疾病表现出广泛的临床病理、生物学和地方性疾病。近年来，T区发育不良、生发中心进行性改变、EB病毒(Epstein-Barr Virus，EBV)等交界性病变在免疫重建宿主和老年患者中频繁出现，成为研究的热点。本研究的目的是识别位于这些交界性病变和恶性淋巴瘤之间的疾病谱。本研究发现了一种以前未描述的以疾病快速进展为特征的EBV相关性淋巴增殖性疾病。在这些病例中，EBV基因组的单克隆性整合被证实。然而，目前尚不清楚它们是真正的肿瘤还是反应性病变，这表明从病理学和生物学的角度区分它们是困难的。另一方面，在老年患者中遇到了几个病例，这些病例目前定义不清，初步诊断为交界性病变，没有任何细胞克隆性增殖的证据。在本研究期间，这些病例导致了无痛的临床病程，其临床病理和生物学性质仍有待阐明。提示交界性淋巴增生性疾病可能或多或少是由病原体引起的免疫系统的解体。还需要进一步的研究。

项目成果

Nakagawa A,et al.: "CD30-positive anaplastic large cell lymphoma in childhood : expression of p80^<npm/alk> and absence of Epstein-Barr virus" Mod Pathol. 10. 210-215 (1997)

Nakakawa A,et al.：“儿童期 CD30 阳性间变性大细胞淋巴瘤：p80^<npm/alk> 的表达和 Epstein-Barr 病毒的缺失”Mod Pathol。

Yatabe Y,et al.: "Clinicopathologic study of PRAD1/cyclin D1 overexpressing lymphoma with special reference to mantle cell lymphoma, a distinct molecular pathologic entity." Am J Surg Pathol. 20. 1110-1122 (1996)

Yatabe Y 等人：“PRAD1/cyclin D1 过表达淋巴瘤的临床病理学研究，特别是套细胞淋巴瘤，一种独特的分子病理实体。”

Nakamura S: "Clinicopathologic study of nasal T/NK-cell lymphoma among the Japanese." Pathol Int. 47. 38-53 (1997)

Nakamura S：“日本人鼻 T/NK 细胞淋巴瘤的临床病理学研究。”

Nakamura, S.et al.: "Clinicopathologic study of nasal T/NK-cell lymphoma among the Japanese." Pathol.Int.47. 38-53 (1997)

Nakamura, S.et al.：“日本人鼻 T/NK 细胞淋巴瘤的临床病理学研究。”

Kurokawa T, et al.: "Complementarity determining determining region-III is a uselful molecular marker for evaluation of minimal residual disease in mantle cell lymphoma" Br J Haematol. 98. 408-412 (1997)

Kurokawa T 等人：“互补决定区 III 是评估套细胞淋巴瘤微小残留病的有用分子标记”Br J Haematol。