悪性リンパ腫におけるMALT1とAPI2遺伝子発現の意義の病理学的、生物学的研究

MALT1和API2基因表达在恶性淋巴瘤中意义的病理生物学研究

• 批准号: 12670191
• 负责人: NAKAMURA Shigeo
• 金额: $ 2.5万
• 依托单位: Aichi Cancer Center Research Institute
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12670191/
• 关键词: Malignant lymphoma; MALT lymphoma; t(11;18) translocation; API2; MALT1; chimeric transcript; Helicobacter pylori; Eradication; T(11;18)(q21;q21); paracaspase; 病理学; 生物学

Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) type constitutes a distinct disease entity. However, its molecular pathogenesis has remained to be elucidaeted. Recently we studied genetic alteration on t(11;18) chromosomal translocation sometimes found on MALT lymphoma, and have identified a novel gene, termed as MALT1 by us, on chromosome 18. Subsequently, we reported that an API2-MALT1 chimeric transcript was mediated by this chromosomal translocation. We further developed the detection system of API2-MALT1 chimeric transcript on the PCR method, and applied the clinisopthologic study of gastric MALT lymphoma. We succeeded to demonstrate that gastric API2-MALT1 chimeric transcript-positive MALT lymphoma generally features unresponsiveness to antibacterial treatment and that this lymphoma is thought to be unrelated to H.pylori infection in its pathogenesis. Further investigation is needed for clarifying the pathogenesis of MALT lymphoma.

结外边缘区粘膜相关淋巴组织（MALT）型B细胞淋巴瘤是一种独特的疾病。然而，其分子发病机制仍有待阐明。最近，我们研究了在MALT淋巴瘤中有时发现的t（11;18）染色体易位的遗传改变，并在18号染色体上鉴定了一个新的基因，我们命名为MALT 1。随后，我们报道了API 2-MALT 1嵌合转录本介导的染色体易位。我们进一步建立了API 2-MALT 1嵌合基因的PCR检测体系，并应用于胃MALT淋巴瘤的临床病理研究。我们成功地证明了胃API 2-MALT 1嵌合转录阳性MALT淋巴瘤通常对抗菌治疗无反应，并且认为这种淋巴瘤的发病机制与幽门螺杆菌感染无关。MALT淋巴瘤的发病机制有待进一步研究。

项目成果

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Kodera Y 等人：“原发性胃淋巴瘤中端粒酶活性的临床相关性”胃癌。

Kojima M, et al.: "Angioimmunoblastic T-cell lymphoma with hyperplastic germinal centers : a clinicopathological and immunohistochemical study of 10 cases"APMIS. 109. 699-706 (2001)

Kojima M 等人：“伴生发中心增生的血管免疫母细胞 T 细胞淋巴瘤：10 例临床病理学和免疫组织化学研究”APMIS。