An investigation of mechanism of permanent threshold shift (PTS) induced by noise exposure

噪声暴露引起的永久阈值漂移（PTS）机制的研究

• 批准号: 04670301
• 负责人: YAMAMURA Koutarou
• 金额: $ 1.34万
• 依托单位: Department of Hygiene, Asahikawa Medical College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1992
• 资助国家: 日本
• 起止时间: 1992 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-04670301/
• 关键词: CM; AP; EP; K^+ ion; Na^+ ion; double-barrel electrode; tone exposure; double barrel electrode; K^+ion exchanger; single barrel electrode; Na^+ion exchanger

Summary Using 97 male albino guinea pigs and applying electrophysiological methods, the effects of a 6 kHz tone were investigated at moderate sound pressure level to the inner ear during a 24-h exposure time. Following exposure to the 6 kHz tone at 90 dB.cochleas showed decreased maximum output voltage of cochlear microphonics (CM) and action potential (AP). In the endolymph. K^+ ion and Na^+ ion concentrations remained unchanged during 40 min anoxia and 90 dB tone exposure. At 80 dB sound exposure decreases in maximum output voltage of CM and AP and decreases in the absolate value of EP could not be detected. Endolymph K^+-ion Na^+-ion concentrations were also unchanged. These finding indicate that diffusion potentials are induced at the same time as decreases of maximum output voltage in CM induced by exposure to sound at 90 dB.

总结使用97只雄性白化病豚鼠并应用电生理学方法，研究了在24小时暴露时间内，在中等声压水平下6 kHz音调对内耳的影响。耳蜗暴露于6kHz、90dB纯音后，耳蜗微音电位（CM）和动作电位（AP）的最大输出电压降低。在内淋巴中。在40 min缺氧和90 dB纯音暴露期间，K^+和Na^+浓度保持不变。在80dB声暴露时，CM和AP的最大输出电压下降，EP绝对值下降。内淋巴液中K^+离子和Na^+离子的浓度也没有变化。这些发现表明，在同一时间引起的扩散电位的最大输出电压在CM暴露于90分贝的声音引起的降低。

项目成果

山村 晃太郎 他 和田 攻 編: "産業保健マニュアル 改訂第2版" 南山堂, 249 (1991)

Kotaro Yamamura 等、Osamu Wada 编：《工业健康手册修订第 2 版》Nanzando，249 (1991)

T.Matsui et al.: "Effects of high-frequency sound on electro-chemical potential using single-barrel method in guinea pigs" ORL. 55. 84-88 (1993)

T.Matsui 等人：“使用单桶法研究高频声音对豚鼠电化学势的影响”ORL。

和田攻 他: "産業保健マニュアル(改訂第2版)" 南山堂, 251 (1991)

Osamu Wada 等人：“工业健康手册（修订第 2 版）” Nanzando，251（1991）

T.Matsui, T.Sugisawa, A.Ishida, K.Nemoto, K.Yamamura: "Effects of High-Frequency Sound on Electro-chemical Potential Using Single-Barrel Method in Guinea Pigs" ORL. 55(2). 84-88 (1993)

T.Matsui、T.Sugisawa、A.Ishida、K.Nemoto、K.Yamamura：“高频声音对豚鼠单管法电化学电位的影响”ORL。

T.Sugisawa et al.: "The effect of 4KHz tone exposure on the guinea pig lnner ear:Relation in the change of CM,AP,EP and Kion concentration induced by noise exposure" ORL. (accepted).

T.Sugisawa 等人：“4KHz 音调暴露对豚鼠内耳的影响：噪声暴露引起的 CM、AP、EP 和 Kion 浓度变化的关系”ORL。