Evidence for Cirdadian Time-Dependent Susceptbility of Blood Pressure to Salt Intake in Normotensive Subjects

这项研究的目的是调查血压对盐摄入量的差异反应是否与膳食中添加钠的时间有关。该研究对7名临床健康、血压正常的女性受试者进行了研究，研究人员在午餐和晚餐时间分别添加了三分之二的食盐。通过无创自动监测（ABPM-630）研究血压对饮食盐变化的反应。在午餐高盐摄入阶段，血压昼夜节律发生显著变化。此外，观察到24小时平均血压水平的不同反应，主要是在午餐（显着增加）或晚餐（显着降低）时转移盐。这些相反的反应证实了这样一种观点，即人类对盐摄入的紧张致敏性与昼夜节律有关。应该在更广泛的背景下研究将盐摄入转移到晚餐，以澄清盐摄入的时间是否可以作为动脉性高血压的非药物治疗，用于更好的营养预防或有效的生活方式改变。

This study is aimed to investigate whether or not there is a differntiated response of blood pressure to salt intake in relation with the time in which dietary sodium added to meals. The study was conducted on 7 clinically healthy normotensive female subjects by adding two-thirds of dietary salt at lunch-time and at dinner-time apart. The blood pressure response to dietary salt shift was studied by means of a non-invasive automated monitoring(ABPM-630). A significant shift of blood pressure circadian rhythm was detected in the stage of high salt intake at lunch-time. Additionally divergent responses in the 24-hour mean level of the blood pressure were observed with shifting salt prevalently at lunch (significant increase) or at dinner (significant decrease). These opposite responses corroborate the view that the tensinogenic susceptibility of human beings to salt intake is time-dependent on a circadian scale. The shift of salt intake to evening meal should be investigated in a broader contex in order to clarify if the timing in salt intake may be exploited for a better nutritional prevention or effective lifestyle modification as the non-pharmacological treatment of arterial hypertension.