Evidence for Cirdadian Time-Dependent Susceptbility of Blood Pressure to Salt Intake in Normotensive Subjects

血压正常的受试者血压对盐摄入量的昼夜时间依赖性敏感性的证据

• 批准号: 04670542
• 负责人: KAWASAKI Terukazu
• 金额: $ 0.45万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1992
• 资助国家: 日本
• 起止时间: 1992 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-04670542/
• 关键词: ambulatory blood pressure monitoring; blood pressure; circadian rhythm; cosinor method; timing in salt intake; nutrition; prevention; 高血圧の予防; 食塩摂取量の日内配分; 24時間血圧値; 尿中Na排泄量; 尿中K排泄量; 尿中電解質の日内変動

This study is aimed to investigate whether or not there is a differntiated response of blood pressure to salt intake in relation with the time in which dietary sodium added to meals. The study was conducted on 7 clinically healthy normotensive female subjects by adding two-thirds of dietary salt at lunch-time and at dinner-time apart. The blood pressure response to dietary salt shift was studied by means of a non-invasive automated monitoring(ABPM-630). A significant shift of blood pressure circadian rhythm was detected in the stage of high salt intake at lunch-time. Additionally divergent responses in the 24-hour mean level of the blood pressure were observed with shifting salt prevalently at lunch (significant increase) or at dinner (significant decrease). These opposite responses corroborate the view that the tensinogenic susceptibility of human beings to salt intake is time-dependent on a circadian scale. The shift of salt intake to evening meal should be investigated in a broader contex in order to clarify if the timing in salt intake may be exploited for a better nutritional prevention or effective lifestyle modification as the non-pharmacological treatment of arterial hypertension.

这项研究的目的是调查血压对盐摄入量的反应是否与膳食中添加钠的时间有关。这项研究是在7名临床健康、血压正常的女性受试者身上进行的，研究人员在午餐时间和晚餐时间分别添加三分之二的食盐。用ABPM-630无创自动监测仪研究了饮食盐变化对血压的影响。午餐高盐摄入量阶段血压昼夜节律发生显著变化。此外，在午餐(显着增加)或晚餐(显着降低)期间普遍改变盐的情况下，观察到24小时平均血压水平的不同反应。这些相反的反应证实了这样一种观点，即人类对盐摄入量的张力性敏感性是与昼夜节律有关的。应在更广泛的背景下研究盐摄入量向晚餐的转变，以便澄清盐摄入量的时机是否可被用于更好的营养预防或有效的生活方式改变，作为动脉高血压的非药物治疗。

项目成果

Uezono K,Kawasaki T et al.: "Circannual differences in circadian variations of blood pressure and beart ratc in Japanese women." Workshop on Computer Methods on Chronobiology and Chronomedicine. 173-183 (1992)

Uezono K、Kawasaki T 等人：“日本女性血压和心率的昼夜变化存在昼夜差异。”

Kawasaki T,Cugini P et al.: "Time-qualified references limits for 24-h,blood pressure patterns derived from a small population sample." J,Ambnlatory Monitoring. 5(1). 11-19 (1992)

Kawasaki T、Cugini P 等人：“源自小群体样本的 24 小时血压模式的时间限定参考限值。”

Mezono,K.,Kawasaki,T.,et al.: "Circannual differences in circadian variations of blood pressure and heart rate in Japanese woman" Workshop on Computer Methods on Chronobiology and Chronomedicine. 173-183 (1992)

Mezono,K.、Kawasaki,T.等人：“日本女性血压和心率昼夜节律变化的昼夜差异”时间生物学和时间医学计算机方法研讨会。

Uezono, K., Kawasaki, T., Otsuka, K., Yanaga, A.: "Circannual differences in circadian variations of blood pressure and heart rate in Japanese women, Edited by Halberg, F., Watanabe, H." Workshop on Computer Methods on Chronobiology and Chronomedicine, Me

Uezono, K.、Kawasaki, T.、Otsuka, K.、Yanaga, A.：“日本女性血压和心率昼夜节律变化的差异，由 Halberg, F.、Watanabe, H 编辑。”

Kawasaki, T., Cugini, P., Uezono, K., Itoh, K., Sasaki, H., DiPalma, L., Battisti, P.: "Time-qualified refernce limits for 24-h blood pressure patterns derived from a small population sample." J.Ambul.Monitor.5(1). 11-19 (1992)

Kawasaki, T.、Cugini, P.、Uezono, K.、Itoh, K.、Sasaki, H.、DiPalma, L.、Battisti, P.：“24 小时血压模式的时间限定参考限值来自