Comparative Study of Salt Sensitivity and Heredity in Nepal

尼泊尔盐敏感性与遗传的比较研究

• 批准号: 09041186
• 负责人: KAWASAKI Terukazu
• 金额: $ 5.38万
• 依托单位: KYUSHU UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for international Scientific Research
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09041186/
• 关键词: Nepal; isolated hill village; hypertension; salt sensitivity; seasonal variation; ACE gene polymorphism; 目給自足的農村; 食塩感受精; 率節変動; アンジオテンシン変換酵素遺伝子多; 丘陵地農村; 正常血圧集団; 生活形態; ミネラル摂取

We found that there were very few hypertensive subjects in the inhabitants of one Nepalese hill (Kotyang) village, even though their salt consumption was as high as the citizens in many westernized countries including Japan. To evaluate the genetic factors involved in this phenomenon, we studied whether or not they had a special genotype distribution of angiotensin converting enzyme (ACE) gene L/D polymorphism, which was recently reported to be involved salt sensitivity. One hundred and thirty-eight subjects (aged in range 20 to 84 years) were evaluated at Kotyang village in Nepal. Only 9 subjects (6.5%) in this population were hypertensives (140/90 mmHg and over) while consuming 11-12g per day of salt, which also confirmed the previous results. The distribution of genotypes and alleles of ACE gene I/D polymorphism was similar to that in the Japanese and Chinese, who had five-to ten-times -more hypertensives while consuming almost as much salt as Nepalese, but signiticantly different from those in Caucasians. The present study reports, for the first time, the genotype distribution of ACE gene I/D polymorphism in Nepalese subjects. Furthermore, the results suggest ACE gene polymorphism may not be involved in the 'salt-resistance' in this population.

我们发现，在尼泊尔一个丘陵（Kotyang）村庄的居民中，很少有高血压患者，尽管他们的盐摄入量与包括日本在内的许多西方化国家的居民一样高。为了评估这一现象的遗传因素，我们研究了它们是否具有最近报道的与盐敏感性有关的血管紧张素转换酶（ACE）基因L/D多态性的特殊基因型分布。在尼泊尔Kotyang村对138名受试者（年龄在20至84岁之间）进行了评估。在这一人群中，只有9名受试者（6.5%）是高血压患者（140/90 mmHg及以上），同时每天摄入11-12g盐，这也证实了之前的结果。ACE基因I/D多态性的基因型和等位基因分布与日本人和中国人相似，日本人和中国人的高血压发病率是尼泊尔人的5 - 10倍，而食盐摄入量几乎与尼泊尔人相当，但与高加索人有显著差异。本研究首次报道了ACE基因I/D多态性在尼泊尔人群中的基因型分布。此外，结果表明ACE基因多态性可能与该人群的“耐盐性”无关。

项目成果

Umemura S, Kawasaki T, Ishigami T, et al: "Angiotensin-converting enzyme gene polymorphism in Nepal" Journal of Human Hypertension. 12. 527-531 (1998)

Umemura S、Kawasaki T、Ishigami T 等人：“尼泊尔血管紧张素转换酶基因多态性”人类高血压杂志。

Umemura S,Kawasaki T,Ishigami T,et al: "Angiotensin-converting enzyme gene polymorphism in Nepal" Journal of Human Hypertension. 12. 527-531 (1998)

Umemura S，Kawasaki T，Ishigami T，et al：“尼泊尔血管紧张素转换酶基因多态性”人类高血压杂志。

マラリア抵抗因子: "寄生中"

疟疾抵抗因子：“寄生”