Expression and synthesis of basic FGF in the placenta and umbilical vessel : Association with pathogenesis of preeclampsia.

1)为了测定人组织中碱性成纤维细胞生长因子(BFGF)的浓度，用两种单抗建立了定量的酶免疫测定法，并证实了该检测系统的实用性。2)通过对子痫前期患者和正常妊娠志愿者胎盘和脐血管组织中碱性成纤维细胞生长因子(BFGF)表达和合成不足的检测，提出了子痫前期患者胎盘和脐血管组织中碱性成纤维细胞生长因子(BFGF)表达和合成不足的关系。因此，血浆纤维连接蛋白水平被认为是子痫前期的一个有前途的生化标志物。

1) In order to determine the concentration of basic fibroblast growth factor (bFGF) in human tissue, a quantitative enzyme immunoassay using two monoclonal antibodies was developed, and the utility of this assay system was confirmed.2) The association of preeclampsia with the insufficient expression and synthesis of basic fibroblast growth factor (bFGF) in placenta and umbilical vessels is suggested following the measurement of bFGF in these tissue from patients of preeclampsia and normal pregnant volunteers.3) Increased levels of fibronectin in plasma was observed in the patients of preeclampsia and the clinical availability of measurement of plasma fibronectin was confirmed through the perspective and longitudinal study in the selected patients who had supposed to have predisposing factor for preeclampsia. Inconsequence, the plasma fibronectin levels is considered as a promising biochemical marker of preeclampsia.