Physiological Roles of Basic FGF on the Development of Uteroplacental Circulation

妊娠期间，子宫胎盘床和胎盘发生快速新生血管形成。尽管子宫和胎盘血管生成的结构成分已被广泛研究，但这些新血管形成的机制仍不清楚。碱性成纤维细胞生长因子(BFGF)在多种类型的细胞上显示出广泛的活性，包括促进细胞生长、诱导纤溶酶原激活剂和促进细胞迁移。尤其是碱性成纤维细胞生长因子是迄今为止最有效的血管生成因子。碱性成纤维细胞生长因子的生物学活性表明，它参与了孕期子宫胎盘循环的发育。本研究采用生物测定法和特异性放射免疫分析法，研究了大鼠和人子宫和胎盘组织中碱性成纤维细胞生长因子含量的变化。结果提示，bFGF可能参与调节孕期子宫和胎盘组织的新生血管形成。

Rapid neovasculization (angiogenesis) takes place in the placental bed of the uterus and the placenta during pregnancy. Whereas the structural components of uterine and placental angiogenesis have been studied extensively, the mechanisms by which these new blood vessels arise still are poorly understood.Basic FGF (bFGF) displays a broad spectrum of activities on many types of cells, including increased growth of cell, induction of plasminogen activator and increased cell migration. Especially, bFGF is the most potent angiogenic factor so far. The biological activities of bFGF suggest that it is involved in the development of uteroplacental circulation in the pregnant period. In this study, the changes of bFGF contents in the uterine and placental tissue of the rat and the human was investigated by bioassay and specific RIA. The results suggest that bFGF may regulate the neovasculization of uterine and placental tissues during pregnancy.