Physiological Roles of Basic FGF on the Development of Uteroplacental Circulation

碱性 FGF 对子宫胎盘循环发育的生理作用

• 批准号: 01570922
• 负责人: YASUMIZU Takehiko
• 金额: $ 1.47万
• 依托单位: Yamanashi Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1989
• 资助国家: 日本
• 起止时间: 1989 至 1990
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-01570922/
• 关键词: Basic FGF; Placenta; Uterus; Bioassay; RIA; 胎 内発育遅延; DHAS半減期; 妊娠中毒症; 胎内発育遅延; Basic-FGF; Basic-FGF測定法

Rapid neovasculization (angiogenesis) takes place in the placental bed of the uterus and the placenta during pregnancy. Whereas the structural components of uterine and placental angiogenesis have been studied extensively, the mechanisms by which these new blood vessels arise still are poorly understood.Basic FGF (bFGF) displays a broad spectrum of activities on many types of cells, including increased growth of cell, induction of plasminogen activator and increased cell migration. Especially, bFGF is the most potent angiogenic factor so far. The biological activities of bFGF suggest that it is involved in the development of uteroplacental circulation in the pregnant period. In this study, the changes of bFGF contents in the uterine and placental tissue of the rat and the human was investigated by bioassay and specific RIA. The results suggest that bFGF may regulate the neovasculization of uterine and placental tissues during pregnancy.

妊娠期间，子宫胎盘床和胎盘发生快速新生血管形成。尽管子宫和胎盘血管生成的结构成分已被广泛研究，但这些新血管形成的机制仍不清楚。碱性成纤维细胞生长因子(BFGF)在多种类型的细胞上显示出广泛的活性，包括促进细胞生长、诱导纤溶酶原激活剂和促进细胞迁移。尤其是碱性成纤维细胞生长因子是迄今为止最有效的血管生成因子。碱性成纤维细胞生长因子的生物学活性表明，它参与了孕期子宫胎盘循环的发育。本研究采用生物测定法和特异性放射免疫分析法，研究了大鼠和人子宫和胎盘组织中碱性成纤维细胞生长因子含量的变化。结果提示，bFGF可能参与调节孕期子宫和胎盘组织的新生血管形成。

项目成果

安水 洸彦、加藤 順三: "Fibroblast growth factorとくにbasic FGFの生物学的作用" 産科と婦人科.

Yasuhiko Yasumi、Junzo Kato：“成纤维细胞生长因子，特别是碱性 FGF 的生物学效应”妇产科。

Takehiko Yasumizu,Junzo Kato: "DHAS halfーlife and intrauterine growth retardation" Act Obst Gynaec Jpn.

Takehiko Yasumizu、Junzo Kato：“DHAS 半衰期和宫内生长迟缓”Act Obst Gynaec Jpn。

Takehiko Yasumizu, Junzo Kato: "Biological functions of basic fibroblast growth factor." Clinical Gynecology and Obstetrics. (1991)

Takehiko Yasumizu、Junzo Kato：“碱性成纤维细胞生长因子的生物学功能。”

安水 洸彦、長坂 正仁、長坂 久司、加藤 順三: "ヒト胎盤内basic fibroblast growth factorの妊娠に伴う変動" 日本産科婦人科学会雑誌.

Yasuhiko Yasumi、Masahito Nagasaka、Hisashi Nagasaka、Junzo Kato：“人类胎盘碱性成纤维细胞生长因子的妊娠相关变化”日本妇产科学会杂志。

安水 洸彦、加藤 順三: "ブタ卵巣の莢膜性growth factor生成に対するゴナドドロピンおよびエストロゲンの影響" 日本産科婦人科学会雑誌.

Yasuhiko Yasumi、Junzo Kato：“促性腺激素和雌激素对猪卵巢荚膜生长因子产生的影响”日本妇产科学会杂志。