THE EFFECT OF PREGNANCY,PARTURITION AND LACTATION ON BONE MINERAL METABOLISM IN HEALTHY WOMEN

妊娠、分娩和哺乳期对健康女性骨矿物质代谢的影响

• 批准号: 08671878
• 负责人: YASUMIZU Takehiko
• 金额: $ 1.41万
• 依托单位: YAMANASHI MEDICAL UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08671878/
• 关键词: Bone matabolism; PICP; ICTP; Bone mineral density; Pregnancy; Postpartum; Lactation

(1) To reassess the clinical utility of serum pyridinoline cross-linked carboxy terminal telopeptide of type I collagen (ICTP), a promising but controversial indicator of bone resorption, we evaluated its performance as a biochemical marker in a 6-month study of a strictly selected population of 76 Japanese postmenopausal and healthy women, 33 recipients of hormone replacement therapy and 43 non-recipients. We measured bone mineral density (BMD) of the lumbar spine (L2-L4), and serum ICTP,carboxyterminal propeptide of type I procollagen (PICP) and other conventional serum biochemical markers at the entry and 6 months later. Among the biomarkers measured, the percent change in ICTP correlated with that in BMD to the highest degree (P<0.0001). We concluded that serum ICTP is a sensitive and useful bone resoption marker in the postmenopausal population, which strongly correlates with the change in BMD.(2) A longitudinal study was performed to investigate postpartum changes in human bone m … More etabolism and the effects of lactation on them. The subjects consisted of two groups : 13 women who stopped breast-feeding within 3 months postpartum (short-term group) and 14 women who continued breast-feeding for more than 6 months postpartum (long-term group). Between prepartum and 3 months postpartum, the values and variations of serum PICP and ICTP were essentially the same in both groups. PICP was maintained at a constant and significantly higher level than the control value. In contrast, ICTP had increased markedly at 5 days postpartum, gradually decreasing thereafter. At 9 months postpartum, PICP and ICTP decreased to the control values in the short-term group. The postpartum time course of lumbar BMD showed a significant decrease in both groups at 3 months at 3 months postpartum and a recovery to the puerperal level in the short-term group but not in the long-term group at 9 months postpartum. In conclusion, bone resorption is stimulated by parturition as well as lactation resuting in postpartum loss of lumbar BMD. Less

(1)为了重新评估血清I型胶原吡啶啉交联羧基末端肽（ICTP）的临床效用，这是一种有前途但有争议的骨吸收指标，我们在一项为期6个月的研究中评估了其作为生化标志物的性能，该研究严格选择了76名日本绝经后健康女性，33名接受激素替代治疗的患者和43名非接受者。在入组时和6个月后测定腰椎（L2-L4）骨密度（BMD）、血清ICTP、I型前胶原羧基端前肽（PICP）和其他常规血清生化指标。在测量的生物标志物中，ICTP的百分比变化与BMD的百分比变化相关性最高（P<0.0001）。我们的结论是，血清ICTP是一个敏感的和有用的骨吸收指标，在绝经后人群，这与BMD的变化密切相关。(2)进行了一项纵向研究，以调查产后人类骨代谢的变化， ...更多信息 以及哺乳对它们的影响。受试者包括两组：13名产后3个月内停止母乳喂养的妇女（短期组）和14名产后6个月以上继续母乳喂养的妇女（长期组）。两组产妇产后3个月内血清PICP和ICTP的值及变化基本相同。PICP维持在恒定且显著高于对照值的水平。相反，ICTP在产后5天显著增加，此后逐渐下降。产后9个月，短期组PICP和ICTP降至对照值。产后3个月时两组腰椎BMD均显著下降，产后9个月时短期组恢复至产褥期水平，但长期组未恢复。总之，分娩和哺乳刺激骨吸收，导致产后腰椎BMD丢失。少

项目成果

Yasumizu T: "Bone metabolism after human parturition and the effect of lactation:longitudinal analysis of serum bone-related proteins and bone mineral content of lumbar spine" Endocrine Journal. 45(in press). (1998)

Yasumizu T：“人体分娩后骨代谢和哺乳的影响：血清骨相关蛋白和腰椎骨矿物质含量的纵向分析”内分泌杂志。

Yasumizu T.: "Concentrations of serum markers of type I collagen synthesisand degradation and serum osteocalcin in matemal and umbilical circulation" Endocrine Journal. 43. 191-195 (1996)

Yasumizu T.：“母体和脐带循环中 I 型胶原合成和降解的血清标志物以及血清骨钙素的浓度”内分泌杂志。

Fukada Y: "The prognosis of fetuses with transient nuchal translucency in the first and early trimester" Acta Obstet Gynecol Scan. 76. 913-916 (1997)

Fukada Y：“妊娠早期和早期妊娠期短暂颈项半透明胎儿的预后”Acta Obstet Gynecol Scan。

Hashi A: "A case of small cell carcinoma of the uterine cervix presenting Cushing's syndrome" Gynecol Oncol. 61. 427-431 (1996)

Hashi A：“一例表现为库欣综合征的宫颈小细胞癌”Gynecol Oncol。

Yasumizu T.: "Serum concentration of carboxyl terminal crosslinked telopeptide of type I collagen (ICTP) is a useful indicator for decline and recovery of bone mineral density in lumbar spine : analysis in Japanese postmenopausal women with or without hor

Yasumizu T.：“I 型胶原羧基末端交联端肽 (ICTP) 的血清浓度是腰椎骨矿物质密度下降和恢复的有用指标：对患有或不患有骨质疏松症的日本绝经后妇女进行分析