A Study of the Influence of Minor Dental Surgery on the Endocrine Hormones in Aged Patients

牙科小手术对老年患者内分泌激素影响的研究

• 批准号: 04671211
• 负责人: FUKUSHIMA Kazuaki
• 金额: $ 1.41万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1992
• 资助国家: 日本
• 起止时间: 1992 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-04671211/
• 关键词: Aged Patients; Minor Dental Surgery; Hypertension; Intravenous Sedation; ACTH; PRA; HANP; コルチゾール; アルドステロン; PRA; HANP; バゾプレシン

The influence of minor dental surgery with local anesthesia on the pituitary-adrenocortical steroid hormones and the hormones responsible for volume homeostasis was investigated in the aged patients.The rsults obtained as follows :1.In the normotensive aged patients, there were many cases in which the value of plasma renin activity (PRA) was already lower than normal range of young adult and manhood before surgery.But, in the hypertensive aged patients, there were also many cases in which the value of PRA was higher than normal range.2.In the normotensive aged patients, the value of human atrial natriuretic peptide (HANP) was already higher than normal range of young adult and manhood before surgery.Furthermore, this tendency was promoted in the hypertensive aged patients.3.The value of ACTH increased during minor dental surgery according to surgical stress in the aged patients, as with young adult and manfood.4.During minor dental surgery, HANP was not changed in the normotensive aged patients, but it increased in the hypertensive aged patients.It was deduced that HANP increased due to the increase of atrial pressure derived from the latent decrease of left ventricular function caused by hypertension and the increase of blood pressure during surgery.5.The increase of ACTH which was observed during minor dental surgery in aged patients was restrained with intravenous sedation.Therefore, the usefullness of intravenous sedation for aged patients was proved in the aspect of pituitary-adrenocortical function.

探讨局麻小牙手术对老年患者垂体-肾上腺皮质类固醇激素及负责体积平衡的激素的影响。实验结果如下：1。在血压正常的老年患者中，有许多患者术前血浆肾素活性（PRA）值已经低于青壮年和壮年的正常范围。但在老年高血压患者中，也有很多患者PRA值高于正常范围。在血压正常的老年患者中，术前人心房利钠肽（HANP）已高于青壮年和壮年的正常范围。此外，这种倾向在老年高血压患者中也有促进作用。老年患者的ACTH值在小牙手术中随着手术压力的增加而升高，青壮年和男性患者也是如此。在小牙手术中，正常老年人的HANP没有变化，而高血压老年患者的HANP升高。推断HANP升高是由于高血压引起的潜伏性左心室功能下降和术中血压升高导致心房压升高所致。在老年患者小牙手术中观察到ACTH的升高，静脉镇静抑制了ACTH的升高。因此，从垂体-肾上腺皮质功能方面证明了静脉镇静对老年患者的有用性。

项目成果

Kazukaki, Fukushima: "A Study of the Influence of Minor Dental Surgery on the Endocrine Hormones in Aged Patients" Journal of Japanese Dental Society of Anesthesiology. (unpublished).

Kazukaki，福岛：“小型牙科手术对老年患者内分泌激素影响的研究”日本牙科麻醉学会杂志。

福島和昭: "歯科小手術の高齢者内分泌系ホルモンに及ぼす影響に関する研究" 日本歯科麻酔学会誌. (発表予定).

福岛和明：《小型牙科手术对老年人内分泌激素影响的研究》日本牙科麻醉学会杂志（待出版）。