A Study of the Influence of minor dental surgery on the Hormones Responsible for Volume Homeostasis

小型牙科手术对负责容量稳态的激素影响的研究

• 批准号: 01571084
• 负责人: FUKUSHIMA Kazuaki
• 金额: $ 1.47万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1989
• 资助国家: 日本
• 起止时间: 1989 至 1991
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-01571084/
• 关键词: Minor Dental Surgery; Vasopressin; Atrial Natriuretic Peptide; Plasma Renin Activity; Aldosterone; Hypertensive Patients; Intravenous Sedation; 心房性ナトリウム利尿ホルモン; バゾプレッシン; R・A-A系ホルモン; ストレス

The influence of minor dental surgery on the hormones responsible for volume homeostasis was investigated, and the difference of the way of secretion on these hormones before or during surgery between normotensive patients and hypertensive patients was also investigated.The results obtained as follows :1. Vasopressin increased significantly during surgery in normotensive patients. and this increase was thought to be caused by stress. However, HANP. PRA. aldosterone did not chang.2. There were many cases in which HANP or PRA was already out of normal range before surgery in hypertensive patients, whereas most of cases were within normal range in normotensive patients.3. The increase of vasopressin which was observed during surgery in normotensive patients was not observed during surgery in hypertensive patients.4. HANP and systric blood pressure increased during surgery in hypertensive patients. and these increases were restrained with intravenous sedation. Therefore, this increase of HANP was likely to be caused by stress and/or the change of blood pressure.5. In 4 cases out Of 5 cases in which PRA was already beyond normal range before surgery in hypertensive patients. PRA decreased during surgery with intravenous sedation. This result suggested that intravenous sedation was useful for the control of PRA and blood pressure during surgery for the patients with essential hypertension. type of high renin concentration.

探讨口腔小手术对体积稳态激素的影响，以及正常患者和高血压患者手术前和手术中这些激素分泌方式的差异。实验结果如下：1。正常血压患者手术期间抗利尿激素显著升高。这种增长被认为是由压力引起的。然而,HANP。PRA。醛固酮无明显变化。高血压患者术前HANP或PRA已超出正常范围的病例较多，而正常患者多数在正常范围内。高血压患者手术中未见血管加压素升高，而正常血压患者手术中可见血管加压素升高。高血压患者手术期间HANP和收缩压升高。静脉镇静抑制了这些增加。因此，这种HANP的增加很可能是由压力和/或血压的变化引起的。5例高血压患者术前PRA已超出正常范围4例。手术期间静脉镇静使PRA降低。提示静脉镇静对原发性高血压患者术中PRA及血压的控制有一定的作用。肾素浓度高的类型。

项目成果

福島 和昭: "歯科小手術の体液調節系ホルモンの変化についてー第2報 高血圧症患者を対象にー" 日本歯科麻酔学会雑誌.

Kazuaki Fukushima：“小型牙科手术期间体液调节激素的变化 - 高血压患者的第二次报告”日本牙科麻醉学会杂志。

福島 和昭: "歯科小手術時の体液調節系ホルモンの変化についてー第1報 正常血圧患者を対象にー" 日本歯科麻酔学会雑誌.

Kazuaki Fukushima：“小型牙科手术期间体液调节激素的变化 - 血压正常患者的第一份报告”日本牙科麻醉学会杂志。

"Changes in the Hormones responsible for Volume Homeostasis during dental Surgery -Part1. Study on normotensive Patients-" Journal of Japanese Dental Society of Anesthesiology.

“牙科手术期间负责容量稳态的激素变化 - 第 1 部分。血压正常患者的研究 -”日本牙科麻醉学会杂志。

"Changes in the Hormones responsible for Volume Homeostasis during dental Surgery -Part2. Study on hypertensive Patients-" Journal of Japanese Dental Society of Anesthesiology.

“牙科手术期间负责容量稳态的激素的变化 - 第 2 部分。高血压患者的研究 -” 日本牙科麻醉学会杂志。