Study on the difference in the circulatory response elicited with trigeminal stimulation

三叉神经刺激引起的循环反应差异的研究

• 批准号: 13672074
• 负责人: FUKUSHIMA Kazuaki
• 金额: $ 2.3万
• 依托单位: HOKKAIDO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13672074/
• 关键词: trigeminal nerve; autonomic nerve; aortic nerve; medullary pathway; hemodynamics; trigeminal depressor response; 減圧神経

Adult white rabbits were used. The mental nerve and the infraorbital nerve were stimulated by 10s of square pulses, 0.1-0.75ms in duration, 1-50Hz in frequency and 1-20V in strength. At the stimulus frequency of 5Hz, strength of 5-10V and duration of 0.25ms, blood pressure decreased most markedly and the response to the stimulation of the infraorbital nerve was larger than that of the mental nerve. At the stimulus of higher frequency and greater strength, blood pressure fell at first and then rose. This discrepancy suggested that pathways of suppressor response and depressor response were different.Subsequently, the aortic nerve was stimulated. The stimulus mode was 10s of the square wave, 10-50Hz in frequency, 1-10V in strength, 0.1-0.75ms in duration. Falling in blood pressure elicited with the stimulation of the aortic nerve became obvious at higher frequency over 25Hz and decrease in heart rate was more remarkable than that elicited with the trigeminal nerve stimulation. It took more time from the beginning of the stimulation to the peak of low blood pressure compared with the trigeminal nerve stimulation. Response of the aortic nerve and that of the trigeminal nerve were different because there were differences in the medullary pathway of the stimulus conduction and in the vagal nerve activity.Furthermore, the electric stimulation of the infraorbital nerve and the aortic nerve was carried out simultaneously. Decreases of blood pressure and heart rate elicited with simultaneous stimulation were greater than that elicited with single nerve stimulation. However, the unique reaction by simultaneous stimulus could not be checked and the relation of the trigeminal depressor response and baroreflex did not become clear.

实验采用成年大白兔。以10s脉冲，0.1 ~ 0.75ms，频率1 ~ 50hz，强度1 ~ 20v刺激心神经和眶下神经。在刺激频率为5Hz、强度为5 ~ 10v、持续时间为0.25ms时，血压下降最为明显，且对眶下神经刺激的反应大于对心神经的反应。在更高频率和更大强度的刺激下，血压先下降后上升。这一差异表明抑制反应和抑制反应的途径不同。随后，刺激主动脉神经。刺激模式为10s方波，频率10-50Hz，强度1-10V，持续时间0.1-0.75ms。在25Hz以上的频率下，主动脉神经刺激引起的血压下降明显，心率下降比三叉神经刺激引起的心率下降更显著。与三叉神经刺激相比，从刺激开始到达到低血压高峰所需的时间更长。由于刺激传导的髓质途径和迷走神经活动不同，主动脉神经和三叉神经的反应不同。同时对眶下神经和主动脉神经进行电刺激。同时刺激引起的血压和心率下降幅度大于单神经刺激引起的血压和心率下降幅度。然而，同时刺激的独特反应不能被检查，三叉神经抑制反应与压力反射的关系也不清楚。