A study of Hemodynamic changes and Regroral Blood Flows, under Hemodilution with Hypotoni

用异氟醚麻醉的Monyrcel犬，观察了急性血液稀释和控制性降压对血流动力学的影响，冠状动脉和心肌血流的反应。通过抽取全血和输注抽取血量的1.5倍的6%羟乙基淀粉，以20 ml/层的速度将血细胞比容稀释至20-22%。随后在平均动脉压为70 mmHg时，用硝普钠静脉滴注，持续降压90分钟。获得了以下结果。（1）SNP降压时PVV_2、SVV_2无明显变化。（2）低血压时心脏纤维蛋白原明显增加。（3）发病率无明显变化。（4）冠状动脉和心肌血流量明显增加，血压降低。（5）SNP未发现氰化物毒性征象。从这些结果。该方法安全可靠，临床实用。

Hemodynamic changes, coronary and myocardial blood flow response to acute hemodilution and controlled hypotension were stuotied in monyrcel dogs anesthetized isoflurane and paralized Pamcurorim. Hemodilution to hematocrit of 20-22% was produced by 20ml/lay by removal of whole blood and infusion of 6% Hydroxyethyl Starch in 1.5 times the volume of blood removed. Subsequently hypotension was produece for 90 minutes by intrracenons infusion of SNP,at mean arterial pressure of 70mmHg. The following results were oftained.(1)PVV_2, SVV_2 were unchanged during hypotension by SNP.(2)Cardiac Fndex alvowed a significant increase during hypotension.(3)Heurt rate did not show significant change.(4)Coronary and myocardial blood How slorowed a significant increuse arring hypotension(5)Sign of cyanide coxicity by SNP were not observed. From these results. This method is safety and useful clinicaly.