Influence on hemodynamic change and tissue PO_2 response during hemodilution with hypotension.

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Hemodynamic changes and tissue PO_2 response under acute hemodilution and controlled hypotension was studied in mongral dogs anesthetized with sevoflurane and paralized pancuronium. Hemodilution was produced by removal of 20ml/kg whole blood and ingusing 6%hydroxyethyl starch saline at 1.5times the volume of blood removed. Subsequenthy hypotension to a mean blood pressure 70mmHg was induced for 90minutes by intravenous infusion of Sodium nitroprusside. The results were as follows.1. Pluse rate was sloght decreused after hemodilution, but should no changes during hypotension.2. CI significant incresed after hemodilution but should no significant changes during hypotension.3. Renal blood flow significantly increased after hemodilution.4. Renal cortex and medilla tissue PO_2 significantly decrused.Hemodynamic changes should no significant after hemodirution and during hypotension.