Influence on hemodynamic change and tissue PO_2 response during hemodilution with hypotension.

低血压血液稀释过程中对血流动力学变化和组织PO_2反应的影响。

• 批准号: 07672185
• 负责人: KUNO Masatoshi
• 金额: $ 1.47万
• 依托单位: Showa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07672185/
• 关键词: Hemodilution; Hypotension; Tissue PO_2; Nitroprusside; SalineHes; 血中希釈; ニトロプロシド; 組織PO_2; 心筋; 乳酸; ピルビン酸

Hemodynamic changes and tissue PO_2 response under acute hemodilution and controlled hypotension was studied in mongral dogs anesthetized with sevoflurane and paralized pancuronium. Hemodilution was produced by removal of 20ml/kg whole blood and ingusing 6%hydroxyethyl starch saline at 1.5times the volume of blood removed. Subsequenthy hypotension to a mean blood pressure 70mmHg was induced for 90minutes by intravenous infusion of Sodium nitroprusside. The results were as follows.1. Pluse rate was sloght decreused after hemodilution, but should no changes during hypotension.2. CI significant incresed after hemodilution but should no significant changes during hypotension.3. Renal blood flow significantly increased after hemodilution.4. Renal cortex and medilla tissue PO_2 significantly decrused.Hemodynamic changes should no significant after hemodirution and during hypotension.

研究了七氟醚联用泮库溴铵麻醉的杂交犬在急性血液稀释和控制性低血压条件下的血流动力学变化和组织PO_2反应。取20ml/kg全血，按1.5倍取血量灌胃6%羟乙基淀粉生理盐水，进行血液稀释。随后静脉滴注硝普钠诱导血压降至平均70mmHg，持续90分钟。实验结果如下：血液稀释后脉搏率明显下降，但在低血压时应无变化。血液稀释后CI显著升高，低血压时CI无明显变化。血液稀释后肾血流量明显增加。肾皮质和中膜组织PO_2明显降低。血液稀释后和低血压时，血流动力学变化不应明显。

项目成果

久野斉俊: "血液希釈併用低血圧麻酔法の組織PO_3の変化" 歯科薬物療法学会誌. (予定).

Masatoshi Kuno：“低血压麻醉联合血液稀释期间组织 PO_3 的变化”日本牙科药理学会杂志（计划）。