Pathogenicity of Pneumonia uirus of mice(PVM) in immunodeficient animals

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[1] INDIRECT FLUORESCENT ANTIBODY METHOD WAS APPLIED FOR A DETECTION OF PNEUMONIA VIRUS OF MOUSE(PVM)ANTIBODY IN COLONIES OF LABORATOREY ANIMALS IN JAPAN.THE RESULTS SHOWED THAT THE ANTIBODY EXIST IN SPF RATS WITH HIGH INCIDENCE.THE ANTIBODY WAS ALSO DETECTED IN OF RABBITS.HOWEVER,THE ANTIBODY WAS NOT DEMONSTRATED IN THE SERA OF MOUSE.THESE RESULTS SUGGESTED THAT PVM INFECTION IS PRESENT IN LABORATORY RATS IN JAPAN AS WELL AS WESTERN COUNTRIES,AND POINTED OUT THE IMPORTANCE OF MICROBIOLOGICAL MONITORING FOR PVM IN FACILITIES FOR ANIMAL EXPERIMENTATION AND ANIMAL BREEDERS.[2] A TRIAL OF VIRUS ISOLATION WAS RESULTED IN POSITIVE.THE CHARACTERISTICS OF NEW ISOLATES (31N,14-3)WERE THE SAME AS THE No.15 ; STANDARD-TYPE OF PVM.THE 31N WAS INFECTED TO MICE AND RATS.AS A RESULT,31N INDUCED THE CONSOLIDATION IN LUNG.ALSO,31N INDUCED INTERSTITIAL PNEUMONIA IN MICE AND RATS.THE SEVERITY WAS HEAVIER IN MICE THAN RATS.AS THE RESULTS,THESE HISTO-PATHOLOGICAL FINDINGS IN RATS SUGGESTED THAT RESULTS WERE VERY IMPORTANT TO INVESTIGATOR OF ANIMAL EXPERIMENTATION AND ADMINISTRATOR OF ANIMAL FACILITY.