Design of Stimulus-responsive Functional Molecule

在本研究中，我们合成了一系列对碱金属和碱土金属阳离子具有良好络合性能的新型大环和开链化合物。这些化合物的显着特点之一是它们对一种刺激如pH的反应。主要结果如下：1.合成了五个含有两个羧酸基团的合成离子载体作为碱土金属离子的载体。2.两种非循环质子电离离子载体如亲脂性喹啉酸和硝基苯酚衍生物通过乳状液膜(ELM)选择性地将锂离子从碱性源相传输到酸性接收相，并与块体L…的实验结果进行了比较更多的液膜(BLM)系统。3.合成了一系列含2-甲基甘醇单元的C-枢轴三脚架配体，并用溶剂萃取法和紫外光谱研究了它们对碱金属离子的络合性能。与三羟甲基乙烷衍生的三脚架配体相比，这些类型的化合物具有更高的萃取性。这一发现清楚地表明，选择合适的基本骨架结构对于C-枢轴三脚架配体的分子设计是重要的。4.合成了新型单氮杂环配体，并通过溶剂萃取法、紫外光谱、X-射线晶体分析和液膜传输研究了它们对碱金属离子的络合性能。一种由两个18-冠-6环和一个20-冠-6环组成的亲油性大双环聚醚通过pH控制的本体液膜被发现是一种高选择性的钾离子载体。较少

In this study, we prepared a variety of new macrocyclic and open-chain compounds with good complexation properties toward alkali metal and alkaline earth metal cations. One of the remarkable characteristics of these compounds is that they respond to a kind of stimulus such as pH.The results are summarized as followes.1.Five synthetic ionophores containing two carboxylic acid groups were synthesized as the carriers for alkaline earth metal cations. Among them, the lipophilic derivative having a trimethylene bridge and plural quinaldate moieties selectively transported barium ion from the basic aqueous phase to the acidic aqueous through the bulk dichloromethane liquid membrane.2.Two types of noncyclic proton-ionizable ionophores such as lipophilic quinaldic acid and nitrophenol derivatives selectively transported lithium ion from the basic source phase to the acidic receiving phase through the emulsion liquid membrane (ELM) and the results were compared with those obtained in the bulk l … More iquid membrane (BLM) system. The transport velocity was extremely increased in comparison with that of the latter system, though the lithium ion selectivity was moderate.3.A series of C-pivot tripodal ligands containing a 2-methylglycelol unit were prepared and their complexation properties towards alkali metal cations were examined by the solvent extraction method and UV spectroscopy. These types of compounds possessed a higher extractability than the other type of tripodal ligand derived from trimethylolethane. This finding clearly shows that the proper selection of the basic skeleton structure is important for the molecular design of C-pivot tripodal ligands.4.New types of monoazacryptands were prepared and their complexation properties toward alkali metal cations were examined by the solvent extraction method, UV spectroscopy, X-ray crystal analysis, and liquid membrane transport. A lipophilic macrobicyclic polyether consisting of two 18-crown-6-rings and one 20-crown-6-ring was found to be a highly selective potassium ion carrier through a bulk liquid membrane by pH control. Less