Structure, function, and pharmacology of neuronal membrane transport proteins

项目摘要 膜转运蛋白负责关键分子的通过和转运蛋白 跨细胞膜的信息，这是许多重要神经生物学事件的中心 流程。它们被设计成选择性地识别各种不同大小的底物和 细胞传输的物理化学性质。我的主要研究目标是了解 涉及疼痛和/或瘙痒的神经细胞膜转运蛋白的设计原则 感觉和传递，开发药理工具来调节它们的功能，并应用 从这项研究中获得的信息，以利用多学科来开发其治疗潜力 方法包括结构生物学、电生理学和药理学。

Project Summary Membrane transport proteins are responsible for the passage of key molecules and the transfer of information across cell membranes, which are events central to many important neurobiological processes. They are designed to selectively recognize a variety of substrates of differing sizes and physicochemical properties for cellular transport. My overarching research goals are to understand the design principles of neuronal membrane transport proteins that are involved in pain and/or itch sensation and transmission, to develop pharmacological tools to modulate their function, and to apply the information gained from this research to exploit their therapeutic potential using a multidisciplinary approach including structural biology, electrophysiology, and pharmacology.