Structure, function, and pharmacology of neuronal membrane transport proteins

神经元膜转运蛋白的结构、功能和药理学

• 批准号: 10403716
• 负责人: Seok-Yong Lee
• 金额: $ 2.82万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-01 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10403716
• 关键词: Applications Grants; Cell membrane; Cell physiology; Cells; Development; Disease; Electrophysiology (science); Epilepsy; Event; Future; G Protein-Coupled Receptor Signaling; Goals; Human; Hyperactivity; Intervention; Maintenance; Mediating; Membrane; Membrane Potentials; Membrane Transport Proteins; Molecular; Mutation; Neurobiology; Neurons; Nociception; Pain; Parents; Patients; Pharmacology; Pharmacology Study; Physiological; Play; Process; Property; Protein Engineering; Proteins; Pruritus; Regulation; Research; Role; Sensory Physiology; Signal Transduction; Signaling Molecule; Structure; System; TYRP1 gene; Therapeutic; Translating; Transmembrane Transport; Transport Process; Transportation; Valverde; career; chronic itch; chronic pain; design; epileptic encephalopathies; interdisciplinary approach; interest; mu opioid receptors; nervous system disorder; pain reduction; pain sensation; parent grant; structural biology; therapeutic development; tool; transmission process

Project Summary Membrane transport proteins are responsible for the passage of key molecules and the transfer of information across cell membranes, which are events central to many important neurobiological processes. They are designed to selectively recognize a variety of substrates of differing sizes and physicochemical properties for cellular transport. My overarching research goals are to understand the design principles of neuronal membrane transport proteins that are involved in pain and/or itch sensation and transmission, to develop pharmacological tools to modulate their function, and to apply the information gained from this research to exploit their therapeutic potential using a multidisciplinary approach including structural biology, electrophysiology, and pharmacology.

项目总结