Structure, function, and pharmacology of neuronal membrane transport proteins
Structure, function, and pharmacology of neuronal membrane transport proteins
批准号:
10403716
负责人:
Seok-Yong Lee
金额:
$2.82万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2021
资助国家:
美国
项目状态:
已结题
起止时间:
2021-06-01 至 2023-05-31
关键词:
Applications GrantsCell membraneCell physiologyCellsDevelopmentDiseaseElectrophysiology (science)EpilepsyEventFutureG Protein-Coupled Receptor SignalingGoalsHumanHyperactivityInterventionMaintenanceMediatingMembraneMembrane PotentialsMembrane Transport ProteinsMolecularMutationNeurobiologyNeuronsNociceptionPainParentsPatientsPharmacologyPharmacology StudyPhysiologicalPlayProcessPropertyProtein EngineeringProteinsPruritusRegulationResearchRoleSensory PhysiologySignal TransductionSignaling MoleculeStructureSystemTYRP1 geneTherapeuticTranslatingTransmembrane TransportTransport ProcessTransportationValverdecareerchronic itchchronic paindesignepileptic encephalopathiesinterdisciplinary approachinterestmu opioid receptorsnervous system disorderpain reductionpain sensationparent grantstructural biologytherapeutic developmenttooltransmission process
中文摘要
项目摘要
膜转运蛋白负责关键分子的通过和转运蛋白
跨细胞膜的信息,这是许多重要神经生物学事件的中心
流程。它们被设计成选择性地识别各种不同大小的底物和
细胞传输的物理化学性质。我的主要研究目标是了解
涉及疼痛和/或瘙痒的神经细胞膜转运蛋白的设计原则
感觉和传递,开发药理工具来调节它们的功能,并应用
从这项研究中获得的信息,以利用多学科来开发其治疗潜力
方法包括结构生物学、电生理学和药理学。
英文摘要
Project Summary
Membrane transport proteins are responsible for the passage of key molecules and the transfer of
information across cell membranes, which are events central to many important neurobiological
processes. They are designed to selectively recognize a variety of substrates of differing sizes and
physicochemical properties for cellular transport. My overarching research goals are to understand
the design principles of neuronal membrane transport proteins that are involved in pain and/or itch
sensation and transmission, to develop pharmacological tools to modulate their function, and to apply
the information gained from this research to exploit their therapeutic potential using a multidisciplinary
approach including structural biology, electrophysiology, and pharmacology.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
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财政年份:2016
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财政年份:2016
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财政年份:2013
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依托单位:
Structure and Function of Concentrative Nucleoside Transporters
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财政年份:2013
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依托单位:
Structure and Function of Concentrative Nucleoside Transporters
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依托单位:
海外基金