Structure, function, and pharmacology of neuronal membrane transport proteins

项目摘要 膜转运蛋白负责关键分子的通过和 细胞膜上的信息，这是许多重要的神经生物学事件的核心。 流程.它们被设计为选择性地识别不同尺寸的各种基板， 用于细胞运输的物理化学性质。我的首要研究目标是 参与疼痛和/或瘙痒的神经元膜转运蛋白的设计原理 感觉和传输，开发药理学工具来调节其功能，并应用于 从这项研究中获得的信息，利用多学科的治疗潜力， 方法包括结构生物学、电生理学和药理学。

Project Summary Membrane transport proteins are responsible for the passage of key molecules and the transfer of information across cell membranes, which are events central to many important neurobiological processes. They are designed to selectively recognize a variety of substrates of differing sizes and physicochemical properties for cellular transport. My overarching research goals are to understand the design principles of neuronal membrane transport proteins that are involved in pain and/or itch sensation and transmission, to develop pharmacological tools to modulate their function, and to apply the information gained from this research to exploit their therapeutic potential using a multidisciplinary approach including structural biology, electrophysiology, and pharmacology.