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The role of tissue renin-angiotensin system on cardiovascular and renal hypertrophy/hyperplasia

组织肾素-血管紧张素系统在心血管和肾脏肥大/增生中的作用

基本信息

批准号：
06670689
负责人：
KOHZUKI Masahiro
金额：
$ 1.34万
依托单位：
TOHOKU UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1995
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06670689/
关键词：
Angiotensin Angiotensin Converting enzyme ACE inhibitor Kinin Losartan Heart failure Renal failure Rat losartan erythropoietin HOE140

项目摘要

1. We assessed the cardio- and reno-protective effects of three kinds of long-acting antihypertensive drugs in rats with chronic renal failure (CRF){an angiotensin II receptor antagonist, an ACE inhibitor, and a calcium channel blocker}. The results indicate that these long-acting antihypertensive drugs equally have the potency to protect heart and kidney in rats with CRF.2. We assessed the potential of the kallikrein-kinin system in mediating the cardio-and reno-protective effects of ACE inhibitors in rats with chronic renal failure (CRF) using ACE inhibitors, a kinin antagonist and an AII receptor antagonist. These results indicate that the kallikrein-kinin system might not play a major role in the cardio-and reno-protective effects of ACE inhibitors in rats with CRF.3. We assessed the cardiac and the renal benefit of an angiotensin II receptor antagonist, losartan, in diabetic rats with renal impairment. The results indicate the hypertension could accelerate diabetic renal impairment and that losartan has antihypertensive and renoprotective effects in this rat model. The difference in potency between losartan treatment and captopril treatment to attenuate the increase in heart weight : body weight ratio might partly explain the existence in the heart of abgiotensin-forming pathways, which are not dependent on angiotensin converting enzyme.4. The effects of prolonged chlorothiazide (CTZ) treatment of left ventricular failure on cardiac hypertrophy, circulating vasoactive hormones and total exchangeable body sodium (NaE) were examined in rats with chronic myocardial infarction induced by left coronary artery ligation. CTZ does not cause regression of cardiac hypertrophy in rats with left ventricular failure and activates the renin angiotensin system.

1.我们评估了三种长效抗高血压药物（血管紧张素II受体拮抗剂、ACE抑制剂和钙通道阻滞剂）对慢性肾功能衰竭（CRF）大鼠的心脏和肾脏保护作用。结果表明，这些长效降压药对CRF大鼠的心、肾均有保护作用.我们评估了激肽释放酶-激肽系统在慢性肾功能衰竭（CRF）大鼠中介导ACE抑制剂的心脏和肾脏保护作用的潜力，使用ACE抑制剂，激肽拮抗剂和AII受体拮抗剂。这些结果表明，激肽释放酶-激肽系统可能在ACE抑制剂对CRF大鼠心脏和肾脏的保护作用中不起主要作用.我们评估了血管紧张素II受体拮抗剂氯沙坦对糖尿病大鼠肾损害的心脏和肾脏的益处。提示高血压可加重糖尿病肾损害，氯沙坦对糖尿病肾损害大鼠具有降压和肾保护作用。氯沙坦治疗和卡托普利治疗之间在减弱心脏重量：体重比增加的效力上的差异可能部分解释了心脏中存在不依赖于血管紧张素转换酶的阿焦紧张素形成途径.本实验观察了氯噻嗪（CTZ）对左冠状动脉结扎所致慢性心肌梗死大鼠心肌肥厚、循环血管活性激素和可交换体总钠（NaE）的影响。CTZ不会导致左心室衰竭大鼠心肌肥厚的消退，并激活肾素血管紧张素系统。