Renal rehabilitation: clarification of mechanism of effectiveness and clinical application

观察运动训练对肾病大鼠肾脏的保护作用，并阐明其作用机制。研究了运动训练对血液透析患者的临床益处。在慢性肾功能衰竭大鼠中，运动训练和血管紧张素II受体拮抗剂的联合治疗具有肾脏保护作用，减轻羰基应激可能介导其肾脏保护作用。在Dahl盐敏感大鼠中，运动训练对肾脏的保护作用不依赖于全身血压，氧化应激和一氧化氮系统的改善可能介导了这种肾脏保护作用。我们开发了一种低撬杆、重量轻、工作负荷可控的自行车功率计，用于血液透析期间的运动训练，并认识到对血液透析患者身体功能和生活质量的有益影响。

Effect of exercise training on renal protection was examined, and mechanism was clarified in rats with renal disease. Clinical benefits of exercise training were examined in hemodialysis patients. In rats with chronic renal failure, a combination therapy with exercise training and angiotensin II receptor blocker had renal protective effects, and an alleviation of carbonyl stress might mediate the renal protective effects. In Dahl salt-sensitive rats, exercise training had renal protective effects with an independent manner of systemic blood pressure, and improvement of oxidative stress and nitric oxide system might mediate the renal protective effects. We developed a low-pried, light weight, work load-controllable bicycle ergometer for exercise training in the hemodialysis period, and recognize beneficial effects of physical functions and QOL in hemodialysis patients.