Effects of EDRF and alpha-sympathetic activity on coronary slosh phenomenon

EDRF 和 α 交感神经活动对冠状动脉晃动现象的影响

• 批准号: 06670753
• 负责人: TSUJIOKA Katsuhiko
• 金额: $ 1.41万
• 依托单位: Kawasaki Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06670753/
• 关键词: coronary slosh; subendocardial coronary flow; EDRF; alpha sympathetic nerve; subendocardial arteriole; cardiac hypertrophy; 内皮由来平滑筋弛緩因子の交換神経

The purpose of this study was to investigate the relation between coronary slosh phenomena and endothelium derived relaxing factor (EDRF). In anesthetized dogs, phasic septal artery blow was measured by 20MHz 80channel ultrasound velocimeter. Subendocardial arteriole was observed by needle-probe videomicroscope in the physiologically beating heart. Subendocardial coronary arteriolar diameter diminished from end-diastole to end-systole by about 20%, indicating that the coronary slosh phenomena is caused by the compression of subendocardial coronary arteriole due to myocardial contraction. Stimulation of alpha sympathetic activity diminishes coronary tonus. In dogs with hypertensive cardiac hypertrophy induced by two kidney two chips, coronary slosh increased. In the same dogs, subendocardial vasodilatory capacity which is dependent on endothelium was jeopardized, whereas endothelium independent capacity was not jeopardized. These results indicate that coronary slosh may be related to both coronary tonus by EDRF and myocardial contraction.

本研究的目的是探讨冠状动脉晃动现象与内皮衍生舒张因子（EDRF）之间的关系。在麻醉犬中，通过 20MHz 80 通道超声测速仪测量阶段性间隔动脉搏动。通过针探针视频显微镜在生理性跳动的心脏中观察心内膜下小动脉。心内膜下冠状动脉直径从舒张末期到收缩末期缩小了约20%，表明冠状动脉晃动现象是由于心肌收缩压迫心内膜下冠状动脉而引起的。刺激α交感神经活动可减弱冠状动脉张力。两肾两片引起的高血压心脏肥大犬，冠状动脉晃动增加。在同一只狗中，依赖于内皮的心内膜下血管舒张能力受到损害，而独立于内皮的能力则没有受到损害。这些结果表明冠状动脉晃动可能与 EDRF 引起的冠状动脉紧张和心肌收缩有关。

项目成果

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