Development of visualization system for neural activity and microcirculation of cerebral cortex.
开发大脑皮层神经活动和微循环可视化系统。
基本信息
- 批准号:08558085
- 负责人:
- 金额:$ 8.9万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (A)
- 财政年份:1996
- 资助国家:日本
- 起止时间:1996 至 1997
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Analysis of cerebral microcirculation is of importance, as higher function of cerebral cortex is completely dependent on blood flow. The purpose of this study was to develop in vivo visualization system for microcirculation and neural activity of cerebral cortex by using needle probe CCD intravital microscope. During the first year we focused on visualization of arteriole and venule and developed a new system, and checked feasibility of the system. This system is composed of a needle-probe with relay lens, three-plate CCD and high difinition monitor. Time and space resolution of this system is 33ms and 2mum, respectively, and distortion of image was not found. In anesthetized dogs, we could clearly observe pial arteriole and venule and movement of red blood cell. Furthermore, we could observe microvessels within cortex by insertion of the needle-probe.In the next year, we investigated the mechanism (s) of regulation of cerebral blood flow. Inhalation of 10% CO_2, intracarotid injection of nitrol or adenosine remarkably increased carotid blood flow. In accordance with this increase, pial arteriole remarkably dilated. Relatively smaller arteriole (diameter<75mum) dilated much, but relatively larger arteriole (diameter*75mum) did not dilate significantly. In conclusion local cerebral blood flow is regulated mainly by relatevely smaller arteriole (<75mum). This mechamism may be beneficial for fine regulation of local cerebral blood flow.
分析大脑微循环是很重要的,因为大脑皮层的高级功能完全依赖于血流。本研究的目的是利用针状探针CCD活体显微镜建立大脑皮层微循环和神经活动的体内可视化系统。在第一年,我们专注于小动脉和小静脉的可视化,并开发了一种新的系统,并验证了系统的可行性。该系统由带继电器镜头的针测头、三板CCD和高清显示器组成。该系统的时间和空间分辨率分别为33ms和2mum,没有发现图像失真。麻醉犬可以清楚地观察到动脉小动脉、小静脉和红细胞的运动。此外,我们还可以通过针头插入观察皮层内的微血管。在接下来的一年里,我们研究了脑血流量调节的机制。吸入10% CO_2、颈动脉内注射硝酸或腺苷均显著增加颈动脉血流量。随着这种增加,动脉细动脉明显扩张。相对较小的微动脉(直径<75mum)扩张较多,而相对较大的微动脉(直径*75mum)扩张不明显。综上所述,局部脑血流主要由相对较小的小动脉(<75mum)调节。这一机制可能有利于局部脑血流的精细调节。
项目成果
期刊论文数量(23)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Y. Saitou: "A needle probe CCD videomicroscope for in vivo observation of microceiculation of the brain." Medical and Biological Engineering and Computing. 35. H64-PS1.08 (1997)
Y. Saitou:“用于体内观察大脑微细胞形成的针探针 CCD 视频显微镜。”
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
山本徳則: "生体ヒト腎vasculo-tubular microcirculationの可視化" 医用電子と生体工学. 34特別号. 88- (1996)
Norinori Yamamoto:“活体肾血管微循环的可视化”医学电子和生物工程 34 期特刊 88-(1996)。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
S. A. Jones: "In vivo measurements of blood flow velocity profiles in canine ilio-femoral anastomotic bypass grafts." Journal of Biomechanical Engineering. 119. 30-38 (1997)
S.A. Jones:“犬髂股动脉吻合旁路移植物血流速度分布的体内测量。”
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
新名健治: "ニードルプローブ型CCD生体顕微鏡による脳微小循環の生体内計測" 医用工学と生体工学. 35特別号. (1997)
Kenji Niina:“使用针探针 CCD 生物显微镜进行体内脑微循环测量”《医学工程与生物工程》第 35 期特刊(1997 年)。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
K. Shimmyo: "In vivo observation of cerebral microcirculation by CCD videomicroscope with a gneedle probe." XXXIII International Congress of Physiological Sciences. IUPS. (1997)
K. Shimmyo:“通过带有针探针的 CCD 视频显微镜对脑微循环进行体内观察。”
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
TSUJIOKA Katsuhiko其他文献
TSUJIOKA Katsuhiko的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('TSUJIOKA Katsuhiko', 18)}}的其他基金
Integrated analysis of three-dimensional molecular dynamics of actin and myosin, and macro-dynamics of cardiac muscle and left ventricle
肌动蛋白、肌球蛋白三维分子动力学、心肌、左心室宏观动力学综合分析
- 批准号:
15300175 - 财政年份:2003
- 资助金额:
$ 8.9万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Research on mechanism for localization of atherosis by micromechanical analysis of vascular endothelial cell
血管内皮细胞微力学分析定位动脉粥样硬化机制
- 批准号:
12480270 - 财政年份:2000
- 资助金额:
$ 8.9万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Analysis of Interaction between Local Blood Flow and Vascular Endothelial Cell by High Speed Three Demensional Dynamic Image Analyzer
高速三维动态图像分析仪分析局部血流与血管内皮细胞的相互作用
- 批准号:
10480249 - 财政年份:1998
- 资助金额:
$ 8.9万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Time-serial analysis of position of LDL and infiltration of monocyte in vascular wall by laser scanning confocal microscope
激光扫描共聚焦显微镜对血管壁LDL位置及单核细胞浸润的时间序列分析
- 批准号:
06558129 - 财政年份:1994
- 资助金额:
$ 8.9万 - 项目类别:
Grant-in-Aid for Developmental Scientific Research (B)
Effects of EDRF and alpha-sympathetic activity on coronary slosh phenomenon
EDRF 和 α 交感神经活动对冠状动脉晃动现象的影响
- 批准号:
06670753 - 财政年份:1994
- 资助金额:
$ 8.9万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)
Coronary arteriolar myogenic response in regulation of coronary circulation
冠状动脉生肌反应对冠状循环的调节
- 批准号:
03670471 - 财政年份:1991
- 资助金额:
$ 8.9万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)
相似海外基金
Brain capillary Piezo1 ion channels and blood flow regulation in Alzheimer’s Disease
阿尔茨海默病中的脑毛细血管 Piezo1 离子通道和血流调节
- 批准号:
10662664 - 财政年份:2023
- 资助金额:
$ 8.9万 - 项目类别:
Blood Flow Regulation and Neuromuscular Function Post-Stroke
中风后的血流调节和神经肌肉功能
- 批准号:
10751266 - 财政年份:2023
- 资助金额:
$ 8.9万 - 项目类别:
Quantitative microfluidic delivery systems for studying tissue microenvironment and microvascular blood flow regulation in vivo
用于研究体内组织微环境和微血管血流调节的定量微流体输送系统
- 批准号:
RGPIN-2017-05205 - 财政年份:2022
- 资助金额:
$ 8.9万 - 项目类别:
Discovery Grants Program - Individual
Influence of exercise training and intensity on cerebral blood flow regulation and cognitive function in mid-life adults with cardiovascular disease.
运动训练和强度对患有心血管疾病的中年成年人脑血流调节和认知功能的影响。
- 批准号:
10449759 - 财政年份:2022
- 资助金额:
$ 8.9万 - 项目类别:
Cerebral blood flow regulation during acute increases in blood pressure: Can cerebral sympathetic nervous activity act as a gatekeeper?
血压急性升高期间的脑血流调节:脑交感神经活动可以充当看门人吗?
- 批准号:
RGPIN-2020-06206 - 财政年份:2022
- 资助金额:
$ 8.9万 - 项目类别:
Discovery Grants Program - Individual
Integrative modeling of the microcirculation: multi-scale dynamics of oxygen-dependent blood flow regulation
微循环的综合建模:氧依赖性血流调节的多尺度动力学
- 批准号:
RGPIN-2019-06086 - 财政年份:2022
- 资助金额:
$ 8.9万 - 项目类别:
Discovery Grants Program - Individual
Mechanisms of embryonic vascular mural cell differentiation and the onset of blood flow regulation
胚胎血管壁细胞分化的机制和血流调节的开始
- 批准号:
RGPIN-2019-07176 - 财政年份:2022
- 资助金额:
$ 8.9万 - 项目类别:
Discovery Grants Program - Individual
Piezo1 proteins: Integration of mechanotransduction in microvascular blood flow regulation.
Piezo1 蛋白:微血管血流调节中机械转导的整合。
- 批准号:
RGPIN-2019-06681 - 财政年份:2022
- 资助金额:
$ 8.9万 - 项目类别:
Discovery Grants Program - Individual
Evolutionary adaptation of cerebral blood flow regulation in hypoxia
缺氧时脑血流调节的进化适应
- 批准号:
547088-2020 - 财政年份:2022
- 资助金额:
$ 8.9万 - 项目类别:
Alexander Graham Bell Canada Graduate Scholarships - Doctoral
Influence of exercise training and intensity on cerebral blood flow regulation and cognitive function in mid-life adults with cardiovascular disease.
运动训练和强度对患有心血管疾病的中年成年人脑血流调节和认知功能的影响。
- 批准号:
10641959 - 财政年份:2022
- 资助金额:
$ 8.9万 - 项目类别: