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Growth Hormone Secretion and Behavioral States in Neonate.

新生儿的生长激素分泌和行为状态。

基本信息

批准号：
06670777
负责人：
KONISHI Yukuo
金额：
$ 0.26万
依托单位：
Fukui Medical School
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1995
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06670777/
关键词：
Infant State Growth Hormone Video Recording Enzyme Immunoassay Central Nervous System State 生理的分泌

项目摘要

This study was aimed to make clear the relation between the behavioral states and growth hormone (GH) secretion in infants. We designed to observe the behavioral states by continuous video recording and at the same time take small amounts of blood every 20 to 30 minutes. But we took only one blood sample at the end of the video recording from each infant because it was impossible for us to take blood samples frequently from the sick infants. Plasma GH concentrations were measured by the highly sensitive sandwich enzyme immunoassay (EIA). From the data of this study, we couldn't confirm the relation between the behavioral states and GH secretion. In our study some infants, especially premature ones, showed the changes of states so frequently that we couldn't judge them as the true state cycle. Previously some study about the relation between states and GH secretion were reported, but the conclusions of each study are inconsistent. It was suggested that the misjudgments of the behavioral states were the reason of that inconsistency. So it is thought that we should reconsider the duration to observe the states and the timing of taking blood samples for GH assay. By accumurating data over a long period, the effects of factors such as postconceptional age, perinatal distress and the disorders of central nervous system will be clear.

本研究旨在明确婴儿行为状态与生长激素（GH）分泌之间的关系。我们设计通过连续视频记录来观察行为状态，同时每20至30分钟抽取少量血液。但我们在视频录制结束时只采集了每个婴儿的一份血样，因为我们不可能频繁地从患病婴儿身上采集血样。血浆 GH 浓度通过高灵敏度夹心酶免疫分析 (EIA) 进行测量。从本研究的数据来看，我们无法证实行为状态与GH分泌之间的关系。在我们的研究中，一些婴儿，尤其是早产儿，表现出如此频繁的状态变化，以至于我们无法判断它们是真实的状态周期。此前已有一些关于状态与GH分泌关系的研究报道，但各研究的结论并不一致。有人认为，行为状态的误判是造成这种不一致的原因。因此我们认为我们应该重新考虑观察状态的持续时间和采集血液样本进行GH检测的时间。通过长期积累的数据，孕后年龄、围产期窘迫、中枢神经系统疾病等因素的影响将会变得清晰。