Spontaneous oscillations of the hemoglobin oxygenation in neonates.

新生儿血红蛋白氧合的自发振荡。

• 批准号: 13671142
• 负责人: KONISHI Yukuo
• 金额: $ 0.9万
• 依托单位: Tokyo Women's Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13671142/
• 关键词: Optical Topography; Hemoglobin; Neonates; Cerebral Blood Flow; Spontaneous Oscillation; BOLD効果

Spontaneous oscillations of the hemoglobin oxygenation state were observed in all the infants. Time series analysis based on the theory of non-linear oscillators showed that the mean periods of the oscillation for each infant ranged from 11 to 18s.Spatially synchronized oscillations of changes in the concentration of oxy- and deoxy- hemoglobin were observed throughout the occipital cortex in the neonates but not in the infants aged 1 month after birth. It was observed that the phase lag of oxy-Hb relative to deoxy-Hb was stable at about 3π/4 in neonates but in the infants aged 1 month, the phase lag was not stable. This phase difference may result from interplay between the vasomotion and the oxygen consumption in relation to brain activity.These findings may be explained by the dynamic morphological and metabolic changes of the visual cortex in early life.

在所有婴儿中都观察到血红蛋白氧合状态的自发振荡。基于非线性振荡理论的时间序列分析表明，每个婴儿的平均振荡周期在11 ~ 18s之间。在新生儿中观察到整个枕皮质氧和脱氧血红蛋白浓度变化的空间同步振荡，而在出生后1个月的婴儿中则没有。结果表明，新生儿氧- hb相对于脱氧- hb的相位滞后稳定在3π/4左右，但1月龄婴儿的相位滞后不稳定。这种相位差可能是由于血管运动和与大脑活动有关的氧气消耗之间的相互作用造成的。这些发现可能与早期视觉皮层的动态形态和代谢变化有关。

项目成果

小西 行郎, 多賀 厳太郎, 牧 敦, 小泉 英明: "光トポグラフィーによる新生児・乳児の視覚野における酸素代謝の自発的律動のメカニズムの検討"インナービジョン. 6月号. 41 (2001)

Yukio Konishi、Gentaro Taga、Atsushi Maki、Hideaki Koizumi：“利用光学地形检查新生儿和婴儿视觉皮层氧代谢自发节律的机制”Inner Vision 6 月号。

Y.Konishi, G.Taga, H.Yamada, K.Hirasawa: "Functional brain imaging using fMRI and optical topography in infancy"SLEEP MEDICINE. 3. S41-S43 (2002)

Y.Konishi、G.Taga、H.Yamada、K.Hirasawa：“婴儿期使用功能磁共振成像和光学地形的功能性脑成像”睡眠医学。

G. Taga, T. Ikejiri, T. Tachibana, S. Shimojo, A. Soeda, K. Takeuchi, Y. Konishi: "Visual feature binding in early infancy"Perception. 31(3). 273-286 (2002)

G. Taga、T. Ikejiri、T. Tachibana、S. Shimojo、A. Soeda、K. Takeuchi、Y. Konishi：“婴儿早期的视觉特征结合”感知。

K. Hirasawa, M. Kurihara, Y. Konishi: "The relationship between mismatch negativity be an index for evaluating the arousal level in infants?"SLEEP MEDICINE. 3. S45-S48 (2002)

K. Hirasawa、M. Kurihara、Y. Konishi：“失配负性之间的关系可以作为评估婴儿觉醒水平的指标吗？”睡眠医学。

K.Hiwasawa, M.Kurihara, Y.Konishi: "The relationship between mismatch negativity be an index for evaluating the arousal level in infants?"SLEEP MEDECINE. 3. S45-S48 (2002)

K.Hiwasawa、M.Kurihara、Y.Konishi：“失配负性之间的关系可以作为评估婴儿觉醒水平的指标吗？”睡眠医学。