Risk factors of neonatal lupus erythematosus

新生儿红斑狼疮的危险因素

• 批准号: 06670876
• 负责人: MIYAGAWA Sachiko
• 金额: $ 0.51万
• 依托单位: Nara Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06670876/
• 关键词: neonatal lupus erythematosus; Ro; SSA; La; SSB; La; SSB; 抗Ro; SSA抗体; リコンビナントRo; シエ-グレン症候群

Bachground : Neonatal lupus erythematosus (NLE) is a syndrome characterized by dermatitis and congenital heart bolck (CHB). The disease is mostly associated with transplacental passage of maternal anti-Ro/SSA and/or La/SSB antibodies. Objective : To examine maternal autoimmune response to recombinant Ro/SSA and La/SSB proteins in NLE with a single ethnic background.Methods : This study examined 12 NLE infants and their mothers. Serum samples were tested by enzyme-linked immunosorbent assay for reactivity with full-length recombinant human 60-kd Ro/SSA,52-kd Ro/SSA,and 48-kd La/SSB proteins.Results : All 10 infants with skin lesions and/or CHB had maternal antibodies reactive to both the 60- and 52-kd Ro/SSA polypeptide components of the Ro/SSA particle. Anti-60-kd Ro/SSA without anti-52-kd Ro/SSA,or vice versa, was found in mothers of infants who had only hepatic manifestation of NLE.Nine of 12 NLE infants had anti-48-kd La/SSB.Conclusion : In the majority of Japanese infants with NLE,maternal anti-Ro/SSA autoimmune response was directed against both of 60-kd and 52-kd recombinant Ro/SSA proteins. There was no profile of anti-Ro/SSA and La/SSB response unique to mothers of children with CHB or cutaneous manifestations of NLE.

背景：新生儿红斑狼疮（NLE）是一种以皮炎和先天性心脏病（CHB）为特征的综合征。该疾病主要与母体抗Ro/SSA和/或La/SSB抗体的经胎盘通过有关。目的：目的：探讨单一民族非淋巴性红斑狼疮（NLE）患儿母亲对重组Ro/SSA和La/SSB蛋白的自身免疫反应。血清样品进行了测试，通过酶联免疫吸附试验与全长重组人60-kd的Ro/SSA，52-kd的Ro/SSA，和48-kd的La/SSB protein.Results的反应：所有10名婴儿皮肤病变和/或CHB的母源抗体反应的60-和52-kd的Ro/SSA多肽成分的Ro/SSA颗粒。在12例NLE婴儿中，9例有抗48 kdLa/SSB抗体。结论：在日本NLE婴儿中，母亲抗Ro/SSA抗体主要针对60 kd和52 kd重组Ro/SSA蛋白。有抗Ro/SSA和La/SSB反应没有独特的CHB或NLE的皮肤表现的儿童的母亲。

项目成果

橋本和子,他: "シ-グレン症候群合併妊娠と先天性完全房室ブロック" 日本小児科学会誌. 99(抄録). 401 (1995)

Kazuko Hashimoto 等人：“妊娠并发 Sigren 综合征和先天性完全性房室传导阻滞”，日本儿科学会杂志 99（摘要）。

宮川幸子(分担): "シェ-グレン症候群・各科別診療の実際" 南江堂, 206 (1996)

宫川幸子（撰稿人）：“干燥综合症/各科的实践” Nankodo，206（1996）

橋本和子他: "シェ-グレン症候群合併妊娠と先天性完全房室ブロック" 日本小児科学会誌. (印刷中)(抄録). (1995)

Kazuko Hashimoto 等人：“妊娠并发干燥综合征和先天性完全性房室传导阻滞”，日本儿科学会杂志（正在出版）（摘要）。

福本隆也,他: "新生児エリテマトーデスにおける60kdおよび52kdSSA/Ro抗原に対する反応性" 日本臨床免疫学会誌. 18(抄録). 456 (1995)

Takaya Fukumoto 等人：“新生儿红斑狼疮中 60kd 和 52kd SSA/Ro 抗原的反应性”，日本临床免疫学会杂志 18（摘要）。

Miyagawa S,et al: "Auti-Ro/SSA associated annular evythoma in childbood." Br J Derinatol. (印刷中). (1995)

Miyakawa S 等人：“儿童时期的 Auti-Ro/SSA 相关环状静脉瘤”（Br J Derinatol）（1995 年出版）。