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Brain dopamine and serotonin metabolism and eating behavior of rats under space restrictin stress

空间限制应激下大鼠脑内多巴胺和血清素代谢及饮食行为

基本信息

批准号：
06670969
负责人：
KIRIIKE Nobuo
金额：
$ 1.28万
依托单位：
Osaka City University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1995
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06670969/
关键词：
Dopamine Serotonin Prefrontal cortex Striatum Nucleus accumbens Time restricted Feeding schedule Space restriction stress Eating behavior 前頭皮質視床下部ストレス

项目摘要

Dopamine and serotonin metabolism in the rat brain (prefrontal cortex, nucleus accumbens, ventrolateral striatum, hypothalamus) were studied using in vivo microdialysis during rebound hyperphagia, (A) followed by 22 hour food deprivation, (B) induced by a time restricted feeding schedule, and (C) under the space restriction as a psychological stress. When female Wister rats were set free from the time restricted feeding schedule, daily food intake significantly increased. This rebound hyperphagia was further enhanced by adding a space restriction stress. Dopamine metabolism increased in the prefrontal cortex and nucleus accumbens of all groups, especially C group, of rats. Whereas dopamine metabolism in the striatum increased only in C group. In the hypothalamus, basal levels of dopamine was low and undetectable. Serotonin metabolism in the prefrontal cortex, increased in B group and further increased in C group. Whereas basal levels of serotonin was very low in nucleus accumbens, ventrolateral striatum, and hypothalamus, there was no significant difference among the 3 groups. These results suggest that eating behavior itself may be related to dopamine metabolism in prefrontal cortex and nucleus accumbens, and serotonin metabolism in prefrontal cortex, and rebound hyperphagia may be related serotonin metabolism in prefrontal cortex, and enhanced rebound hyperphagia under the space restriction stress may be related dopamine metabolism in prefrontal cortex and striatum, and serotonin metabolism in prefrontal cortex.

采用体内微透析的方法研究了反跳性贪食(A) 22小时食物剥夺、(B)限时进食、(C)空间限制心理应激下大鼠大脑（前额叶皮质、伏隔核、腹外侧纹状体、下丘脑）多巴胺和血清素代谢。当雌性Wister大鼠不受时间限制喂养时，日摄食量显著增加。通过增加空间限制应力，这种反跳性贪食进一步增强。各组大鼠前额叶皮层和伏隔核多巴胺代谢增加，其中以C组明显。而纹状体多巴胺代谢仅在C组增加。在下丘脑，多巴胺的基础水平很低，无法检测到。前额叶皮层血清素代谢，B组升高，C组进一步升高。虽然伏隔核、腹外侧纹状体和下丘脑的血清素基础水平很低，但3组间无显著差异。上述结果提示，进食行为本身可能与前额皮质和伏隔核多巴胺代谢、前额皮质5 -羟色胺代谢有关，反跳性贪食可能与前额皮质5 -羟色胺代谢有关，空间限制应激下反跳性贪食增强可能与前额皮质和纹状体多巴胺代谢、前额皮质5 -羟色胺代谢有关。