PHYSIOLOGICAL EFFECTS OF CHOLESTERYL ESTER TRANSFER PROTEIN ON ATHEROSCLEROSIS

胆固醇酯转移蛋白(CETP)是调节血浆高密度脂蛋白-胆固醇水平的因素之一。为了确定可能调节CETP活性的因素，并确定CETP在多大程度上与脂蛋白的生理浓度相关，我们对586名健康志愿者(317名男性和269名女性，平均年龄52.2岁和10.9岁)进行了流行病学研究。这些受试者的CETP活性为192.96正负48.73(平均值正负SD)nmoL/ml/hr，分布范围很广(60~450nmol/ml/hr)。经多元回归分析发现，CETP活性与低密度脂蛋白(P&lt；0.03)、载脂蛋白E(P&lt；0.005)和LCAT活性(P&lt；0.001)呈显著正相关。CERP活性与ApoA-1呈显著负相关(p&lt；0.03)。CETP活性与高密度脂蛋白胆固醇和载脂蛋白B均无显著相关，单因素方差分析显示饮酒和吸烟显著降低CETP活性，而CETP活性与体重指数无显著相关性。尽管女性的CETP活性显著高于男性(p&lt；0.001)，但多元回归分析显示男性和女性的CETP活性与年龄均无相关性。我们的结果表明，CETP活性调节载脂蛋白A-1和低密度脂蛋白-胆固醇的浓度，并且这种活性可能受性别、饮酒和雪茄的影响

Cholestryl ester transfer protein (CETP) is one of factors that regulates plasma levels of HDL-choesterol. To idntify the factors that may regulate CETP activity, and to determine to what extent CETP is correlated with pysiologic concentrations of lipoprotein, we performed an epidemilogic study in 586 healty volunteers (317 males and 269 females, mean age 52.2<plus-minus>10.9 yrs) . CETP activity in these subjects was 192.96<plus-minus>48.73 (mean<plus-minus>SD) nmol/ml/hr and distributed to a wide range (60 to 450 nmol/ml/hr) . Using multiple regression analysis, we found significant positive correlations between CETP activity and LDL-cholesterol (p<0.03) , apolipoprotein (apo) E (p<0.005) and LCAT activity (p<0.001) . CERP activities showed significant negative correlation with apo A-1 (p<0.03) . However , CETP activity showed no significant correlation either with HDL cholesterol or with apo B.One-way layout analysis of variance showed that alcohol drinking and cigarette smoking significantly reducd CETP activity, but there was no significat association between CETP activity and body mass index. Although CETP activities were significantly higher in females than in males (p<0.001) , multiple regression analysis showed no correlation between CETP activity and age in either the males or the females. Our results suggest that CETP activity regulates the concentration of apo A-1 and LDL-cholesterol, and that such activity may be influenced by gender, alcohol consumption and cigaratte sm