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PHYSIOLOGICAL EFFECTS OF CHOLESTERYL ESTER TRANSFER PROTEIN ON ATHEROSCLEROSIS

胆固醇酯转移蛋白对动脉粥样硬化的生理作用

基本信息

批准号：
06671052
负责人：
KINOSHITA Makoto
金额：
$ 1.15万
依托单位：
TEIKYO UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1995
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06671052/
关键词：
CHOLESTERYL ESTER TRANSFER PROTEIN ATHEROSCLEROSIS REVERSE CHOLESTEROL TRANSPORT HIGH DENSITY LIPOPROTEIN LOW DENSITY LIPOPROTEIN ALCOHOL SMOKING GENDER HDL LDL アポ蛋白リポ蛋白飲酒

项目摘要

Cholestryl ester transfer protein (CETP) is one of factors that regulates plasma levels of HDL-choesterol. To idntify the factors that may regulate CETP activity, and to determine to what extent CETP is correlated with pysiologic concentrations of lipoprotein, we performed an epidemilogic study in 586 healty volunteers (317 males and 269 females, mean age 52.2<plus-minus>10.9 yrs) . CETP activity in these subjects was 192.96<plus-minus>48.73 (mean<plus-minus>SD) nmol/ml/hr and distributed to a wide range (60 to 450 nmol/ml/hr) . Using multiple regression analysis, we found significant positive correlations between CETP activity and LDL-cholesterol (p<0.03) , apolipoprotein (apo) E (p<0.005) and LCAT activity (p<0.001) . CERP activities showed significant negative correlation with apo A-1 (p<0.03) . However , CETP activity showed no significant correlation either with HDL cholesterol or with apo B.One-way layout analysis of variance showed that alcohol drinking and cigarette smoking significantly reducd CETP activity, but there was no significat association between CETP activity and body mass index. Although CETP activities were significantly higher in females than in males (p<0.001) , multiple regression analysis showed no correlation between CETP activity and age in either the males or the females. Our results suggest that CETP activity regulates the concentration of apo A-1 and LDL-cholesterol, and that such activity may be influenced by gender, alcohol consumption and cigaratte sm

胆固醇酯转运蛋白（CETP）是调节高密度脂蛋白胆固醇水平的因子之一。为了确定可能调节CETP活性的因素，并确定CETP与脂蛋白生理浓度的相关程度，我们对586名健康志愿者（317名男性和269名女性，平均年龄52.2 ± 10.9岁）进行了流行病学研究<plus-minus>。这些受试者的CETP活性为192.96 <plus-minus>- 48.73（平均<plus-minus>SD）nmol/ml/hr，分布范围很广（60 - 450 nmol/ml/hr）。多元回归分析发现CETP活性与LDL-胆固醇（p<0.03）、载脂蛋白E（p<0.005）和LCAT活性（p<0.001）呈显著正相关。CERP活性与apoA-1呈显著负相关（p<0.03）。单因素方差分析显示，饮酒和吸烟可显著降低CETP活性，但与体重指数无显著相关性。尽管女性CETP活性显著高于男性（p<0.001），但多元回归分析显示，无论男性还是女性，CETP活性与年龄均无相关性。我们的研究结果表明，CETP活性调节载脂蛋白A-1和低密度脂蛋白胆固醇的浓度，这种活性可能受到性别，饮酒和吸烟的影响。