Role of serum PAF acctylhydrolase on atherosclerosis

血清PAF乙酰水解酶在动脉粥样硬化中的作用

• 批准号: 08671182
• 负责人: KINOSHITA Makoto
• 金额: $ 1.41万
• 依托单位: TEIKYO UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08671182/
• 关键词: PAF acetylhydrolase; atherosclerosis; oxidized LDL; 動脈硬化症; PAFアセチルヒドロラーゼ; リゾリン脂質; ホルモン補充療法

Platelet activating factor (PAF) acetylhydrolase is known as an inactivator of PAF.Serum PAF acetylhydrolase is carried by lipoproteins, mainly by low density lipoprotein (LDL), and it is known to release lysophosphatidylcholine from oxidized LDL.Therefore, it is possible that PAF acetylhydrolase play roles on lipid metabolism and formation of atherosclerosis.Using serum of PAF acetylhydrolase deficient patient, it was revealed that PAF acetylhydrolase deficient serum was less susceptible to oxidation by copper. And probucol or interferon made serum PAF acetylhydrolase activity higher than control. These results indicate that PAF acetylhydrolase play some roles on lipid metabolism and is regulated by some drugs. Futher in vitro experiment is necessary to evaluate the direct effects of PAF acetylhydrolase on atherosclerosis.

血小板活化因子（PAF）乙酰水解酶被称为血小板活化因子的失活剂。血清PAF乙酰水解酶由脂蛋白携带，主要由低密度脂蛋白（LDL）携带，已知它能从氧化的LDL中释放溶血磷脂酰胆碱。因此，PAF乙酰水解酶可能参与脂质代谢和动脉粥样硬化的形成。通过对PAF乙酰水解酶缺乏患者的血清分析，发现PAF乙酰水解酶缺乏患者的血清对铜的氧化作用较弱。普罗布考和干扰素使血清PAF乙酰水解酶活性高于对照组。提示PAF乙酰水解酶在脂质代谢中起一定作用，并受药物调节。研究PAF乙酰水解酶对动脉粥样硬化的直接作用还需要进一步的体外实验。

项目成果

木下誠: "Lp(a)測定は血栓傾向のマーカーとなるのか" 内科. 78. 453-455 (1996)

Makoto Kinoshita：“Lp(a) 测量是血栓倾向的标志吗？” 78. 453-455 (1996)。

木下 誠: "プラーク形成の防御機構" 臨床医. 24. 19-22 (1998)

Makoto Kinoshita：“斑块形成的防御机制”临床医生。24. 19-22 (1998)

Goto da T.et al.: "Skipping of exon 14 and possible instability……" Arteriosclerosis Thrombosis. 17. 1376-1381 (1997)

Goto da T. 等人：“外显子 14 的跳过和可能的不稳定......”动脉硬化血栓形成。 17. 1376-1381 (1997)

木下誠 他: "運動とCETP,LCAT,LPL,HTGL" The Lipid. 7. 25-30 (1996)

Makoto Kinoshita 等人：“运动和 CETP、LCAT、LPL、HTGL”脂质。

木下 誠: "LDL予防試験" Mebio. 14. 73-78 (1997)

木下诚：“低密度脂蛋白预防研究”Mebio 14. 73-78 (1997)