Anti-tumor effect of green tea and juice on.rat urinary bladder tumor inducd by BBN

绿茶及果汁对BBN诱导的大鼠膀胱肿瘤的抗肿瘤作用

• 批准号: 06671619
• 负责人: MATSUSHIMA Masahiro
• 金额: $ 1.28万
• 依托单位: Toho University, School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06671619/
• 关键词: Anti-tumor effect; urinary bladder tumor; green-tea; vegitable juice; BBN; epigallocathechin; 野菜ジュース; にんじんジュース; オレンジジュース; ラット; 茶

1) we divided Wistar rats into 6 groups and BBN was added to their drinking water in a concentration of 0.05% for 5 weeks. After that, the drinking water was replaced by tap water for the control group, green tea for group 2, macha for group 3, hoji cho for group 4, oolong tea for group 5 and black tea for group 6.Results : All rats were sacrificed at 40 weeks. Regarding the number and size of the tumors per rat, ther were significant differences between the groups such as green tea and hoji cha , and the control group. However, ther were no significant differences between the groups such as macha, oolong tea and black tea, and the control group. There were also significant differences regarding the tumor size per rat between the groups such as green tea and hoji cha, and the groups sush as oolong tea and black tea.Conclusions : The green tea had anti-tumor effect of urinary bladder in rat induced by BBN.The half-fermented tea (oolong tea) and the fermented tea (black tea) did not have … More anti-tumor effect of urinary bladder tumor. Epigallocathechin and epigallocathechin gallate : main polyphenolic constituent of green tea infusion and inhibit tumor promotion, is much lower in black tea and oolong tea than green tea.2) We devided Wistar rats into 4 groups and BBN was added to their drinking water in a concentration of 0.05% for 5 weeks. After that, the drinking water was replaced by tap water for the control group, vegetable juice for group 2, carrot juice for group 3 and fluit juice for group 4.Results : all rats were sacrificed at 40 weeks. Regarding the number and size of the tumor per rat, ther were significant differences between the group 2 and the control group. However, ther were no significant differences between the groups such as carrot and fulit juice, and the control group.Conclusions : The vegetable juice had anti-tumor effect of urinary bladder tumor induced in rat by BBN.However, the carrot juice and fluit juice had no anti-tumor effect of urinary bladder tumor induced in rat by BBN. Less

1)将Wistar大鼠分为6组，在饮水中添加浓度为0.05%的BBN，连续5周。之后，对照组用自来水代替饮用水，第二组用绿茶，第三组用马茶，第四组用河姬草，第五组用乌龙茶，第六组用红茶。结果：所有大鼠均于40周处死。就每只大鼠的肿瘤数量和大小而言，绿茶和茶等组与对照组之间存在显著差异。而茶、乌龙茶、红茶等组与对照组之间无显著差异。在每只大鼠的肿瘤大小方面，绿茶和茶组以及乌龙茶和红茶组之间也存在显著差异。结论：绿茶具有抗BBN大鼠膀胱肿瘤的作用。半发酵茶（乌龙茶）和发酵茶（红茶）对膀胱肿瘤的抗肿瘤作用不明显。没食子儿茶素和没食子儿茶素没食子酸酯：绿茶中主要的多酚类成分，具有冲泡和抑制肿瘤促进作用，在红茶和乌龙茶中的含量远低于绿茶。2)将Wistar大鼠分为4组，在饮水中加入浓度为0.05%的BBN，连续5周。之后，对照组用自来水代替饮用水，2组用蔬菜汁代替，3组用胡萝卜汁代替，4组用果汁代替。结果：所有大鼠均于40周处死。在每只大鼠的肿瘤数量和大小方面，2组与对照组有显著差异。然而，胡萝卜和果汁等组与对照组之间没有显著差异。结论：蔬菜汁对BBN致大鼠膀胱肿瘤有抗肿瘤作用。然而，胡萝卜汁和果汁汁对BBN诱导的大鼠膀胱肿瘤无抗肿瘤作用。少

项目成果

Masayuki Harada, Naoko Tokuda and Masahiro Matsushima: "Anti-tumor effect of green tea on rat urinary bladder tumor induced by N-buthl-N- (4-hydroxybutyl) nitrosamine" J.Med.Soc.Toho. (in press).

Masayuki Harada、Naoko Tokuda 和 Masahiro Matsushima：“绿茶对 N-丁基-N-（4-羟丁基）亚硝胺诱导的大鼠膀胱肿瘤的抗肿瘤作用”J.Med.Soc.Toho。

Masahiro Matsushima: "The inhibitory effect of green tea on vesical oncogensis" Proceeding of Akutual Urologie. (in press). (1996)

Masahiro Matsushima：“绿茶对膀胱癌发生的抑制作用”Akutual Urologie 论文集。

松島正浩,原田昌幸,徳田直子: "膀胱発癌に対する緑茶の抑制効果" Molecular Medicine. 31. 1274 (1994)

Masahiro Matsushima、Masayuki Harada、Naoko Tokuda：“绿茶对膀胱癌的抑制作用”《分子医学》31. 1274 (1994)。

Masahiro Matsushima: "The inhibitory effect of green tea on vesical oncogenesis" Proceeding of Akutual Urologie. (in press).

Masahiro Matsushima：“绿茶对膀胱肿瘤发生的抑制作用”Akutual Urologie 论文集。

松島正浩,原田昌幸,徳田直子: "膀胱発癌とお茶の効用" Molecular Medicine. 32. 987-988 (1995)

Masahiro Matsushima、Masayuki Harada、Naoko Tokuda：“膀胱癌发生和茶的影响”《分子医学》32. 987-988 (1995)。