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Anti - tumor Effect of Japanese favorite foods (buckwheat flour, soybean flour, unpolished rice tea and green tea) in BBN-induced rat bladder tumor

日本人喜爱的食物（荞麦粉、大豆粉、糙米茶和绿茶）对BBN诱导的大鼠膀胱肿瘤的抗肿瘤作用

基本信息

批准号：
12671562
负责人：
MATSUSHIMA Masahiro
金额：
$ 1.02万
依托单位：
Toho University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2000
资助国家：
日本
起止时间：
2000 至 2001
项目状态：
已结题

项目摘要

Green tea has enjoyed a long history as a favorite drink in Japan and its therapeutic effects have frequently been reported with regard to its antibacterial, anti-inflammatory, anti-allergic and anti-hypertensive effect.This experiment suggested that green tea may inhibit tumor growth and have the strongest anticancer. Green tea improved the histologic grade of carcinomas and tends to decrease the depth of invasion. Green tea may inhibit tumor initiation. Comparison by the period giving green tea in advance of the carcinogen has not been investigated and it requires a further investigation.Traditional foods, such as buckwheat flour, Kinako and unpolished rice tea taken habitually in Japan have been reported to be good for health. These foods are vaguely said to be effective and have hardly been studied, despite their having always been integrated into our daily lives. Previously we reported on the anti-tumor effect of green tea. This time we study these foods from the aspect of their anti-tumor effect and also in comparison with green tea. With Buckwheat flour and Kinako, no statistically significant differences was found as to the tumor incidence and adverage number of tumors produced, but the total tumor volume decreased by more than half, so they are considered effective as health foods. In the group with unpolished rice tea added, statistically significant differences were comfirmed, so their anticancer effects can be expected.Atypia and the depth of invasion of BBN-induced bladder cancer was significantly decreased in group 4 (green tea) and group 5 (green tea and unpolished rice tea).

绿色茶作为日本人喜爱的饮料有着悠久的历史，其抗菌、抗炎、抗过敏和抗高血压的治疗效果经常被报道。本实验表明，绿色茶可以抑制肿瘤生长，具有最强的抗癌作用。绿色茶改善了癌的组织学分级，并倾向于降低浸润深度。绿色茶可以抑制肿瘤的发生。通过在致癌物之前给予绿色茶的时间进行比较尚未调查，需要进一步调查。据报道，日本习惯性食用的传统食品，如荞麦粉、Kinako和糙米茶对健康有益。这些食物被含糊地说是有效的，几乎没有被研究，尽管它们一直融入我们的日常生活。以前我们报道过绿色茶的抗肿瘤作用。本文从抗肿瘤作用的角度，并与绿色茶进行比较研究。荞麦粉和Kinako在肿瘤发生率和产生的肿瘤粘附数量方面没有统计学显著差异，但总肿瘤体积减少了一半以上，因此它们被认为是有效的健康食品。加入糙米茶的组中，统计学上的显著性差异被证实，因此其抗癌作用是可以预期的。第4组（绿色茶）和第5组（绿色茶和糙米茶）中BBN诱导的膀胱癌的异型性和浸润深度显著降低。