Regeneration of central and peripheral nerve after nerve anastomosis

目的探讨舌下面神经吻合术和舌旁面神经吻合术在面神经损伤后面部康复中的应用价值。我们采用经典舌下面部吻合术和y型硅胶管对豚鼠进行舌下面部吻合术和辅助面部解剖。从眨眼反射测量和组织学研究中获得的数据表明，术后6个月舌下神经再生面神经的质量良好。此外，在80%的动物中，连接吻合口的面神经近端残端再生了一个新的神经束。术后4周和8周舌下面吻合术再生神经束直径和轴突数量均显著大于副面吻合术。舌下-面部吻合的传导速度也快于副翼-面部吻合。这些结果表明舌下面部吻合术比副翼面部吻合术更适合面部康复手术。

To clarify the usefulness of hypoglossal-facial anastomosis and accessory-facial anastomosis for facial rehabilitation when the facial nerve is sacrificed. We carried out hypoglossal-facial anastomosis and accessory-facial anatomosis in guinea pigs using classic hypoglossal-facial anastomosis method and Y-shaped silicone tube. Data obtained from both blink reflex measurement and histological study demonstrate a good quality of regeneration of the facial nerve from the hypoglossal nerve completed 6 months after the operation. In addition a new nerve bundle was regenerated from the proximal stump of the facial nerve connecting to the anastomotic site in 80% of the animals. The diameter of regenerated nerve bundle and number of axon in the hypoglossal-facial anastomosis were significantly greater than those of accessory-facial anastomosis at both 4 and 8 weeks postoperation. The conduction velocity of the hypoglossal-facial anastomosis was also faster than that of accessory-facial anastomosis. These results suggest that hypoglossal-facial anastomosis is more favorable surgical choice for facial rehabilitation than accessory-facial anastomosis.