Novel treatment for facial nerve palsy by HSV neuritisUnderstanding its mechanism

肝细胞生长因子（HGF）在中枢神经系统有促进神经功能恢复的作用，但在外周神经系统中的作用尚不清楚。我们使用复制缺陷型单纯疱疹病毒载体将HGF转染到压碎的面神经中。面神经麻痹的恢复在临床、电生理学和病理学上都得到了加速。HSV感染与突发性耳聋、前庭神经炎的关系密切。将HSV-1或HSV-2分别注入小鼠鼓室。在这些小鼠中观察到眩晕和听力损失。HSV感染，凋亡细胞中发现的血管纹，然而，凋亡细胞周围发现的Corti的器官没有感染HSV。HSV感染后的细胞凋亡诱导根据细胞类型而不同。

Hepatocyte growth factor (HGF) has been reported to accelerate recovery in central nerve system, but its function in peripheral nerve system is unclear. We transfected HGF using replication-defective herpes simplex virus vector into crushed facial nerve. Recovery from facial nerve palsy was accelerated clinically, electrophysiologically, and pathologically. Transfected cells were detected using immunohistochemicalstaining.Close relationship between HSV and sudden deafness or vestibular neuritis has been reported. We inject HSV-1 or HSV-2 into tympanic cavity of mice. Vertigo and hearing loss was observed in those mice. HSV-infected, apoptotic cells were found in stria vascularis; however, apoptotic cells found around Corti’s organ was not infected with HSV. Apoptosis induction after HSV infection differed according cell types.