Search for new antiarrhythmic drugs based on inhibition of trigger in atrial fibrillation

本研究对TRPM 4通道抑制剂类抗房颤药物进行了研究，以期为开发新型抗房颤药物提供参考。TRPM 4通道可被升高的细胞内Ca ~（2+）浓度激活，因此可触发心房颤动。由于TRPM 4通道在人心室中不起作用，因此TRPM 4通道的选择性抑制剂预期在心室中引起有限的副作用。利用人心房模型和TRPM 4通道模型，我们发现TRPM 4通道抑制剂可以抑制心房颤动，可能成为一种很好的抗心律失常药物。

In this study, in order to facilitate the development of new antiarrhythmic drugs specific for atrial fibrillation, we studied the potential of TRPM4 channel inhibitors antiarrhythmic drugs. TRPM4 channel can be activated by elavated intracellular Ca^<2+> con(as) cen(new) tration and therefore can be triggers for atrial fibrillation, Since TRPM4 channels are not functional in the human ventricular, selective inhibitors of TRPM4 channels are expected to cause limited side effect in the ventricular. By using the human atrial model and TRPM4 channel model, we showed that inhibitors of TRPM4 channel may suppress atrial fibrillation and may be a good candidate for new antiarrhythmic drugs.