Search for new antiarrhythmic drugs based on inhibition of trigger in atrial fibrillation

在本研究中，为了促进新型房颤特异性抗心律失常药物的开发，我们研究了TRPM4通道抑制剂抗心律失常药物的潜力。TRPM4通道可被细胞内Ca^<2+>浓度升高激活，因此可能是房颤的触发因素。由于TRPM4通道在人心室中不起作用，TRPM4通道的选择性抑制剂预计在心室中引起有限的副作用。通过人体心房模型和TRPM4通道模型，我们发现TRPM4通道抑制剂可能抑制心房颤动，可能是新的抗心律失常药物的良好候选。

In this study, in order to facilitate the development of new antiarrhythmic drugs specific for atrial fibrillation, we studied the potential of TRPM4 channel inhibitors antiarrhythmic drugs. TRPM4 channel can be activated by elavated intracellular Ca^<2+> con(as) cen(new) tration and therefore can be triggers for atrial fibrillation, Since TRPM4 channels are not functional in the human ventricular, selective inhibitors of TRPM4 channels are expected to cause limited side effect in the ventricular. By using the human atrial model and TRPM4 channel model, we showed that inhibitors of TRPM4 channel may suppress atrial fibrillation and may be a good candidate for new antiarrhythmic drugs.