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Analysis of retinal diseases using suppressive rod-cone interaction

利用抑制性视杆-视锥相互作用分析视网膜疾病

基本信息

批准号：
06671759
负责人：
HORIGUCHI Masayuki
金额：
$ 1.22万
依托单位：
Nagoya University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1995
项目状态：
已结题

项目摘要

In this study, we observed suppressive rod-cone interaction (SRCI) in patients with complete type and imcomplete type congenital stationary night blindness (CSNB) and high myopia. In complete CSNB,normal magnitude of SRCI was observed in all except one case who showed localized area of abnormal SRCI.In incomplete CSNB,normal SRCI was also observed in all except one case. Most cases with high myopia reavealed patchy area of abnormal SRCI in visual field. These results suggest that localized abnormality of SRCI in one case with complete CSNB was not related to this retinal disorder itself but to myopia which always associated with this disorder. In incomplete CSNB which always had no myopia, the mechanism of abnormal SRCI we observed in one case in unkown. SRCI was produced by horizontal cells, The axons of which may be damaged by deformity of the eye ball in high myopia. Recent study on photoic REG demonstrated that complete CSNB has dysfunction in one type bipolar cells, which receptor to glutamate is completely different from that of horizontal cells. This findings can explain the discrepancy between absent rod sensitibity and normal SRCI in complete CSNB.ERG findings and SRCI in incomplete CSNB,reduced scotopic b-wave, off-type photopic ERG and normal SRCI,may inhicate mild dysfunction of both on and off type bipolar cells and normally functioning horizontal cells. This awaits further investigations.

在这项研究中，我们观察了完全型和不完全型先天性静止性夜盲症（CSNB）和高度近视患者的抑制性视锥细胞相互作用（SRCI）。在完全性CSNB中，除1例出现局部异常SRCI外，其余所有病例均观察到正常的SRCI强度。在不完全性CSNB中，除1例外，所有病例均观察到正常的SRCI。大多数高度近视患者视野内可见斑片状异常SRCI区域。这些结果表明，1例完全CSNB患者的SRCI局部异常与这种视网膜疾病本身无关，而是与近视有关，而近视总是与这种疾病相关。在一直没有近视的不完全CSNB中，我们在一例中观察到异常SRCI的机制尚不清楚。 SRCI是由水平细胞产生的，高度近视患者的眼球畸形可能会导致其轴突受损。最近对光REG的研究表明，完全CSNB在一种双极细胞中存在功能障碍，其谷氨酸受体与水平细胞完全不同。这一发现可以解释完整CSNB中杆体敏感性缺失和正常SRCI之间的差异。ERG结果和不完全CSNB中的SRCI、暗视b波减少、关闭型明视ERG和正常SRCI，可能会导致开启和关闭型双极细胞和正常功能水平细胞的轻度功能障碍。这有待进一步调查。