Analysis of retinal diseases using suppressive rod-cone interaction

在本研究中，我们观察了完全型和不完全型先天性静止性夜盲症（CSNB）和高度近视患者的抑制杆锥相互作用（SRCI）。在完全性CSNB中，除1例SRCI局部异常外，其余均为正常程度。在不完全性CSNB中，除1例外，其余SRCI均正常。高度近视眼多表现为视野内片状的SRCI异常区。这些结果表明，1例完全性CSNB患者的SRCI局部异常与该视网膜疾病本身无关，而与近视有关，近视常与该疾病相关。在一贯无近视的不完全CSNB中，我们观察到1例SRCI异常的发生机制尚不清楚。SRCI是由水平细胞产生的，其轴突可能因高度近视的眼球畸形而受损。最近的研究表明，完全CSNB在一类双极细胞中有功能障碍，这种细胞对谷氨酸的受体与水平细胞完全不同。这一发现可以解释完全性CSNB中无棒敏感性与正常SRCI之间的差异。不完全CSNB的ERG结果和SRCI、暗位b波减少、异型光性ERG和正常SRCI可能暗示了开关型双极细胞和正常功能水平细胞的轻度功能障碍。这有待进一步调查。

In this study, we observed suppressive rod-cone interaction (SRCI) in patients with complete type and imcomplete type congenital stationary night blindness (CSNB) and high myopia. In complete CSNB,normal magnitude of SRCI was observed in all except one case who showed localized area of abnormal SRCI.In incomplete CSNB,normal SRCI was also observed in all except one case. Most cases with high myopia reavealed patchy area of abnormal SRCI in visual field. These results suggest that localized abnormality of SRCI in one case with complete CSNB was not related to this retinal disorder itself but to myopia which always associated with this disorder. In incomplete CSNB which always had no myopia, the mechanism of abnormal SRCI we observed in one case in unkown. SRCI was produced by horizontal cells, The axons of which may be damaged by deformity of the eye ball in high myopia. Recent study on photoic REG demonstrated that complete CSNB has dysfunction in one type bipolar cells, which receptor to glutamate is completely different from that of horizontal cells. This findings can explain the discrepancy between absent rod sensitibity and normal SRCI in complete CSNB.ERG findings and SRCI in incomplete CSNB,reduced scotopic b-wave, off-type photopic ERG and normal SRCI,may inhicate mild dysfunction of both on and off type bipolar cells and normally functioning horizontal cells. This awaits further investigations.