Analysis of retinal diseases using suppressive rod-cone interaction

在这项研究中，我们观察了完全型和不完全型先天性静止性夜盲和高度近视患者的抑制性视杆-视锥相互作用(SRCI)。在完全性CSNB中，除1例显示局限性SRCI异常外，其余均为正常；在不完全性CSNB中，除1例外，其余均为正常。高度近视患者多可见视野中SRCI异常的斑片区。这些结果表明，1例完全性CSNB患者的SRCI局部性异常与视网膜病变本身无关，而与近视有关。在一直无近视的不完全性CSNB中，我们观察到1例SRCI异常的机制未知。SRCI是由水平细胞产生的，高度近视时，水平细胞的轴突可能因眼球畸形而受损。最近对光REG的研究表明，在一种类型的双极细胞中，完整的CSNB存在功能障碍，其对谷氨酸的受体与水平细胞完全不同。这一发现可以解释完全性CSNB的视杆细胞敏感度缺失与正常SRCI之间的差异。不完全CSNB、暗视b波减少、OFF型明视ERG和正常SRCI的ERG表现和SRCI可能与开、关型双极细胞和正常水平细胞的轻度功能障碍有关。这有待进一步调查。

In this study, we observed suppressive rod-cone interaction (SRCI) in patients with complete type and imcomplete type congenital stationary night blindness (CSNB) and high myopia. In complete CSNB,normal magnitude of SRCI was observed in all except one case who showed localized area of abnormal SRCI.In incomplete CSNB,normal SRCI was also observed in all except one case. Most cases with high myopia reavealed patchy area of abnormal SRCI in visual field. These results suggest that localized abnormality of SRCI in one case with complete CSNB was not related to this retinal disorder itself but to myopia which always associated with this disorder. In incomplete CSNB which always had no myopia, the mechanism of abnormal SRCI we observed in one case in unkown. SRCI was produced by horizontal cells, The axons of which may be damaged by deformity of the eye ball in high myopia. Recent study on photoic REG demonstrated that complete CSNB has dysfunction in one type bipolar cells, which receptor to glutamate is completely different from that of horizontal cells. This findings can explain the discrepancy between absent rod sensitibity and normal SRCI in complete CSNB.ERG findings and SRCI in incomplete CSNB,reduced scotopic b-wave, off-type photopic ERG and normal SRCI,may inhicate mild dysfunction of both on and off type bipolar cells and normally functioning horizontal cells. This awaits further investigations.