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Study on macular blue-cone using multifocal blue-cone electroretinogram

多焦点蓝锥体视网膜电图对黄斑蓝锥体的研究

基本信息

批准号：
13470372
负责人：
HORIGUCHI Masayuki
金额：
$ 5.7万
依托单位：
Fujita Health University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2001
资助国家：
日本
起止时间：
2001 至 2003
项目状态：
已结题

项目摘要

Diabetic retinopathy can be accurately diagnosed by fluorescein angiogram(FA). However, FA cannot be frequently repeated. Electroretinogram may be a useful tool for diagnosis of diabetic retinopathy. Since the diabetic change starts from local area of the ocular fundus and its severity varies from area to area, full-field ERG is not suited for study of diabetic retinopathy. Focal ERG is needed. Multifocal ERG(mfERG) can record focal ERG from many areas of the fundus simultaneously and is suited for diagnosis of diabetic retinopathy. We studied patients with diabetic retinopathy using blue cone mfERG that is recorded by silent substitution of color ORT monitor. Blue cone System is more vulnerable than red and green cone systems. Blue cone focal ERG (first order kernel), was abnormal in the area without visible abnormality of the retina, indicating that it is very sensitive to diabetic change. However, our study revealed that white lesions, such as hard or soft exudates, causes stray light effect on the focal responses. Our experiments also showed that the second order kernel is free from stray light effect. Therefore, we tried to extract the second order kernel of blue cone mfERG but were not successful because of its small amplitude. Our conclusion in this study is that the first order kernel of blue cone mfERG is very sensitive to diabetic change but is affected by white lesions, and the second order kernel of blue cone mfERG should be investigated.

糖尿病视网膜病变可以通过荧光素血管造影（FA）准确诊断。然而，FA不能经常重复。视网膜电图对糖尿病视网膜病变的诊断有一定的价值。由于糖尿病性视网膜病变是从眼底局部开始的，且不同部位病变的严重程度不同，因此全视野ERG不适合用于糖尿病视网膜病变的研究。需要进行Focal ERG。多焦视网膜电图（mfERG）可同时记录眼底多个区域的局灶性ERG，适用于糖尿病视网膜病变的诊断。我们研究了糖尿病视网膜病变患者使用蓝锥mfERG，记录的无声替代彩色ORT监测器。蓝锥系统比红锥和绿色锥系统更脆弱。蓝锥局灶性ERG（一阶核）在视网膜无可见异常的区域异常，表明其对糖尿病变化非常敏感。然而，我们的研究表明，白色病变，如硬或软渗出物，引起杂散光效应的焦点反应。实验还表明，二阶核不受杂散光的影响。因此，我们试图提取蓝锥mfERG的二阶核，但由于其幅度小而没有成功。结论：蓝视锥mfERG的一阶核对糖尿病的改变非常敏感，但受白色病变的影响，蓝视锥mfERG的二阶核应进一步研究。