Study for multifocal electroretinogram in diabetic maciclopathy

糖尿病黄斑病变的多焦视网膜电图研究

• 批准号: 10671642
• 负责人: HORIGUCHI Masayuki
• 金额: $ 2.05万
• 依托单位: Fujita Health University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10671642/
• 关键词: diabetic retinopathy; multifocal ERG; the first order kernel; the second order kernel; neuropathy; 二次核; neuropathy; 糖尿病; 黄斑浮腫; optical coherent tomography; 硝子体手術; 網膜厚; random ERG; 糖尿病黄斑症

We investigated feasibility of multifocal electroretinogram (m-ERG) for diagnosis of diabetic maculopathy. The experiments in animal using glutamate analogues and neurotransmitters revealed that the first order kernel (FOK) originates from the outer layers of the retina and the second order kernel comes (SOK) comes from the inner layers. M-ERG in diabetic patients without retinopathy showed a delay in FOK and a delay and a reduction in SOK.The alteration of SOK was located in the temporal area. These results arise a possibility that early m-ERG changes may be induced by retinal neuropathy which initiates from the temporal area. We found some correlation between m-ERG and the data in photo-stress recovery test which has been found to have some contribution from the inner layers. Finally, we developed a new test, photo-stress recovery test using m-ERG, for further study in diabetic maculopathy.

探讨多焦视网膜电流图(m-ERG)诊断糖尿病黄斑病变的可行性。用谷氨酸类似物和神经递质进行的动物实验表明，一级核(FOK)来自视网膜外层，二级核(SOK)来自内层。无视网膜病变的糖尿病患者M-ERG表现为FOK延迟、SOK延迟和减少，SOK改变位于颞区。这些结果提出了一种可能性，即早期的m-ERG改变可能是由起始于颞区的视网膜神经病变引起的。我们发现m-ERG与光应激恢复测试的数据有一定的相关性，这也被发现来自内层的贡献。最后，我们开发了一种新的测试，即利用m-ERG的光应激恢复测试，以进一步研究糖尿病黄斑病变。

项目成果

Miyaka Y: "Electrore tinograhpic alternations during vitreoctomy in humans"Graeft Arch Clin Exp Ophthacmol. 236. 13-17 (1998)

Miyaka Y：“人类玻璃体切除术期间的 Electrore 显像交替”Graeft Arch Clin Exp Ophthacmol。

Horioguchi M, Suzuki S, Kondo M, Tanikawa A, Miyake Y: "Effect of glutamate analogues and inhibitory neurotransmitters on the random electroretinogram in rabbits"Invest Ophthalmol Vis Sci. 39. 2171-2176 (1998)

Horioguchi M、Suzuki S、Kondo M、Tanikawa A、Miyake Y：“谷氨酸类似物和抑制性神经递质对兔子随机视网膜电图的影响”Invest Ophasemol Vis Sci。

Mineo Kondo, Chang-Hua Piao, Atsushi Tanikawa, Masayuki Horiguchi, Hiroko Terasaki and Yozo Miyake: "Amplitude Decrease of Photopic ERG b-wave at Higher Stimulus Intensities in Humans"Jpn J Ophthalmol. 44. 20-28 (2000)

Mineo Kondo、Chang-Hua Piao、Atsushi Tanikawa、Masayuki Horiguchi、Hiroko Terasaki 和 Yozo Miyake：“人类较高刺激强度下明视 ERG b 波的振幅降低”Jpn J Ophthalmol。

Terasaki H: "Focal electroretinogrout before and after successful cuaculm hale surgery"Am.J Ophthalmol. 125. 204-213 (1998)

Terasaki H：“成功的 cuaculm hale 手术前后的局灶性电视网膜灌浆”Am.J Ophamol。

Horiguchi M: "Effect of glutamate aualogues and inhibitory neurotransmitters on the random electroretinogram in rabbits"Invest Ophthalmol Vis Sci. 39. 2171-2176 (1998)

Horiguchi M：“谷氨酸类似物和抑制性神经递质对兔子随机视网膜电图的影响”Invest Ophasemol Vis Sci。