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Developmental alteration of function and distribution of taste buds on the soft palate.

软腭味蕾功能和分布的发育改变。

基本信息

批准号：
06671865
负责人：
HARADA Shuitsu
金额：
$ 1.34万
依托单位：
Kagoshima University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1995
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06671865/
关键词：
Soft palate Tongue Taste bud Rat Mammal GSP Amiloride Development 授乳大錘体神経

项目摘要

Developmental changing of fuction and distribution of taste buds on the soft palate and fungiform papilla were investigated in the rat. Taste buds on the soft palate produced robust gustatory responses to sugars, especially for sucrose, and various D-amino acids. They showed little sensitivity for amiloride which markedly inhibit taste responses to Na salts. On the contrary, taste buds on the fungiform papilla indicated low taste sensitivities for sugars and amino acids, while remarkable inhibition by amiloride for Na salts A was observed. The number of taste buds of the fungiform papillae was approximately 100, and reached 200 at three weeks of age. However, maturated taste buds were only 15% of all and reached 90% at two weeks of age. On the other hand, 180 taste buds were distributed on the soft palate and 80% of those were maturated at birth and reached 90% at two weeks of age. The number of taste buds on circumvallate papillae was only 40 at birth and reached 400 at four weeks of age. No taste bud was observed on the foliate papillae at birth and observed 300 at three weeks of age. Although the numbers of taste buds were different among species, similar difference of maturation of taste buds between the soft palate and the tongue was observed in the mouse and gerbil. In the marmoset, the number of the taste buds of fungiform papillae was approximately three times larger than that on the soft palate at tree days of age, while maturated buds were 80% in the soft palate and 60% in the fungiform papillae. Although the number of taste buds apparently decreased at two months of age and reached one third at nine months, while the decreasing of buds in the fungiform papillae was slight. These results indicated that the function of the taste buds on the soft palate was quite different from those in the tongue, playing important role on neonatal stage in mammals.

本实验观察了大鼠软腭和菌状乳头味蕾功能和分布的发育变化。软腭上的味蕾对糖，特别是蔗糖和各种D-氨基酸产生了强烈的味觉反应。它们对阿米洛利几乎不敏感，阿米洛利显著抑制对Na盐的味觉反应。相反，菌状乳头上的味蕾对糖和氨基酸的味觉敏感性较低，而阿米洛利对钠盐A的抑制作用显著。菌状乳头的味蕾数量约为100个，在3周龄时达到200个。然而，成熟的味蕾只有15%，在两周大时达到90%。另一方面，180个味蕾分布在软腭上，其中80%在出生时成熟，两周龄时达到90%。出生时，轮廓乳头上的味蕾数量只有40个，4周龄时达到400个。出生时在叶状乳头上没有观察到味蕾，三周龄时观察到300个味蕾。虽然味蕾的数量在物种之间存在差异，但在小鼠和沙鼠中观察到软腭和舌头之间味蕾成熟的相似差异。在绒猴中，菌状乳头的味蕾的数量约为3倍以上的软腭在3日龄，而成熟的芽是80%的软腭和60%的菌状乳头。虽然味蕾的数量在2月龄时明显减少，9月龄时达1/3，但菌状乳头中的味蕾数量减少幅度较小。这些结果表明，软腭上味蕾的功能与舌上味蕾的功能有很大的不同，在哺乳动物的新生期起着重要的作用。