Slective Brain Cooling in Hyperthermic Subjects and Its Inter-individual Difference

高温受试者的选择性脑冷却及其个体间差异

• 批准号: 06680125
• 负责人: HIRASHITA Masami
• 金额: $ 1.22万
• 依托单位: KANAZAWA COLLEGE OF ECONOMICS
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06680125/
• 关键词: Hyperthermia; Selective brain cooling; Sweat rate; Venous blood flow; Tympanic temperature; Esophagus temperature; Postural change; Heat stroke; 運動; 体温調節; 環境温; 浸透圧; 心部体温

During hyperthermia, venous blood from the face and scalp flows into the intracranium through the ophthalmic and emissary veins, which is supposed to be an important response provoding selective brain cooling in humans. To understand a possible mechanism of this response, healthy male volunteers were subjected to either passive body warming or exercise, in a climatic chamber whose air temperature and relative humidity were 28ﾟC and 40%. During either passive body warming or exercise, forehead sweat rate and forehead skin blood flow started to increase shortly after the start of heat loading. A rather abrupt increase of venous flow through the opthalmic veins into the intracranium occurred significantly later than the increases on forehead sweat rate and skin blood flow. Tympanic temperature at this abrupt increase in ophthalmic venous flow did not differ between the test. Mean skin temperature at this flow increase was, however, significantly higher during passive body warming than in exercise. The abrupt increase of inward venous through the ophthalmic veins was not observed in nearly 20% of subjects. The reason for this inter-individual difference of this response is discussed.

在高热期间，来自面部和头皮的静脉血通过眼静脉和导静脉流入颅内，这被认为是引起人类选择性脑冷却的重要反应。为了了解这种反应的可能机制，健康的男性志愿者在空气温度和相对湿度为28 ℃和40%的气候室中进行被动身体加温或运动。在被动的身体温暖或运动期间，前额出汗率和前额皮肤血流量在热负荷开始后不久开始增加。通过眼静脉进入颅内的静脉流量的突然增加明显晚于前额出汗率和皮肤血流量的增加。在眼静脉血流量突然增加时，两组的鼓膜温度没有差异。平均皮肤温度在这个流量的增加，但是，显着高于在被动的身体变暖比运动。近20%的受试者未观察到眼静脉向内静脉的突然增加。这种反应的个体间差异的原因进行了讨论。

项目成果

平下 政美: "運動時熱中症をおこす各種要因" 金沢経済大学雑誌"telos". 15. 7-15 (1995)

平下雅美：“运动时引起中暑的各种因素”金泽经济大学杂志“telos”15. 7-15（1995）。

平井敦夫: "食物摂取が運動時の蒸発性熱放散量に及ぼす影響" 体力科学. 43. 680 (1994)

Atsuo Hirai：“运动时食物摄入量对蒸发散热的影响”《体能科学》43. 680 (1994)。

Hirashita M.: "Various factor of heat stroke during exercise." Research Institute for human and cultural scineces, Kanazawa college of economics.15. 7-15 (1995)

Hirashita M.：“运动过程中中暑的多种因素。”

平下 政美 他: "マウスの寒冷暴露の体脂肪代謝に与えるβ遮断剤の効果" 金沢経済大学論集. 28(2). 121-134 (1994)

Masami Hirashita 等人：“β-受体阻滞剂对寒冷暴露小鼠体内脂肪代谢的影响”金泽经济大学杂志 28（2）121-134（1994）。

平下 政美他: "高温環境下での長時間競技時の発汗量、飲水量および浸透圧の変化" 金沢経済大学雑誌"telos". 15. 37-43 (1995)

Masami Hirashita等：“高温环境下长期比赛时出汗量、饮水量和渗透压的变化”金泽经济大学学报“telos”15. 37-43（1995）。