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Emissary venous flow and selective brain cooling in hyperthermic human subjects.

高温人类受试者的静脉静脉流动和选择性脑冷却。

基本信息

批准号：
02454128
负责人：
NAGASAKA Tetsuo
金额：
$ 4.48万
依托单位：
Kanazawa University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1990
资助国家：
日本
起止时间：
1990 至 1992
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-02454128/
关键词：
Hyperthermia Passive Body Warming Exercise Selective brain Cooling Emissary veins Sweating Body Posture Change

项目摘要

We measured skin blood flow and sweating rate of the head, blood flow in the angular oculi and mastoid emissary veins, esophageal, tympanic, and mean skin temperatures during whole body hyperthermia in male volunteers. 1. When angular oculi flow was obstructed for 8-10 min while core temperatures were still rising, the rate of rise in tympanic temperature increased than before but that in esophageal temperature did not change. When angular oculi flow was increased by skin compression over the facial veins at an alinasl level, the rate of rise in tympanic temperature decreased than before but esophageal temperature did not change. 2. Tympanic temperature at which a sharp increase of flow occurred in angular oculi veins was the same in either passive body warming or exercise. 3. Temperature difference between the esophagus and the tympanum [Tes-Tty] became less in the subjects with heavy make-up than in those without. 4. When body posture was changed from supine to a 30ﾟ head-up position, blood flows in angular oculi and mastoid emissary veins were increased with a fall in the rate of rise in tympanic temperature. When the subjects remained supine, [Tes-Tty] remained small for the entire period of whole body hyperthermia. 5. During body warming, mean skin temperature reached 37-38ﾟC and skin blood flow and sweating rate of the face reached a plateau even when core temperatures were still rising. We suggest that the fall in brain temperature by selective brain cooling would not suppress the heat loss responses as far as brain temperature is within the range of temperature at which the heat loss responsesare at their maximum level. From these results, we conclude that selective brain cooling is possible and important in humans. Selective brain cooling is achieved by inflow of venous blood, cooled on the scalp and face by evaporation of sweat, through the emissary and ophtahalmic veins into the intracranium.

我们测量了男性志愿者全身热疗期间的皮肤血流量和头部出汗率、眼角和乳突导静脉、食道、鼓室的血流量以及平均皮肤温度。 1.当眼角血流受阻8-10分钟而核心温度仍在升高时，鼓室温度升高速率较之前增加，但食管温度升高速率没有变化。当鼻腔水平处的面部静脉上的皮肤受压而增加眼角流量时，鼓室温度上升的速率比以前下降，但食管温度没有变化。 2.无论是被动保暖还是运动，眼角静脉流量急剧增加时的鼓室温度都是相同的。 3.化浓妆的受试者食道和鼓膜之间的温差[Tes-Tty]比未浓妆的受试者更小。 4.当体位从仰卧变为30°仰卧位时，眼角和乳突导静脉的血流量增加，鼓室温度上升速率下降。当受试者保持仰卧位时，[Tes-Tty] 在整个全身热疗期间保持较小。 5. 在身体变暖期间，即使核心温度仍在上升，平均皮肤温度仍达到37-38°C，皮肤血流量和面部出汗率达到稳定水平。我们认为，只要大脑温度处于热损失反应达到最大水平的温度范围内，通过选择性脑冷却来降低脑温度就不会抑制热损失反应。从这些结果中，我们得出结论，选择性大脑冷却对于人类来说是可能且重要的。选择性脑冷却是通过静脉血流入实现的，通过汗液蒸发在头皮和面部冷却，通过使静脉和眼静脉进入颅内。