Morphological analysis of the neuronal circuits in the brainstem motor system

脑干运动系统神经元回路的形态学分析

• 批准号: 06680740
• 负责人: YASUI Yukihiko
• 金额: $ 1.41万
• 依托单位: Shimane Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06680740/
• 关键词: substantia nigra; superior colliculus; red nucleus; reticular formation; orofacial movement; neuronal circuit; rat

We had reported the direct pathway from the substantia nigra pars reticulata (SNr), where the neurons related to orofacial movements had been known to exist, to the parvicellular reticular formation (RFp), where many premotor neurons for the orofacial motor nuclei had been reported to be distributed. In the present study, we further examined the indirect pathways from the SNr to the RFp in the rat.The present results indicated that the lateralmost part of the superior colliculus and dorsal part of the red nucleus, where the ipsilateral nigral fibers from the dorsolateral part of the SNr terminated, sent projection fibers to the contralateral RFp. We further showed that these nigral axons were immunoreactive for GABA and made symmetrical synaptic contacts with somata and dendrites of the tectal and rubral neurons sending their axons to the RFp.In addition to the direct pathway from the SNr to the RFp, the SNr was suggested to exert control influences upon orofacial movements indirectly through the nigrotectobulbar and nigrorubrobulbar pathways to the RFp.

我们已经报道了从黑质网状部（SNr）到小细胞网状结构（RFp）的直接通路，SNr是已知存在与口面运动相关的神经元的地方，RFp是许多口面运动核的运动前神经元的分布地。本研究进一步探讨了大鼠SNr到RFp的间接投射途径。结果表明，来自SNr背外侧部的同侧黑质纤维终止于上级丘的近外侧部和红核的背侧部，向对侧RFp发出投射纤维。我们进一步发现，这些黑质轴突对GABA呈免疫反应性，并与顶盖和红核神经元的胞体和树突形成对称性突触接触，将轴突送到RFp，除了SNr到RFp的直接通路外，SNr还通过黑质-顶盖-延髓和黑质-红核-延髓通路间接地对口面运动产生控制作用。

项目成果

Yukihiko Yasui, Toshiko Tsumori, Akiro Ando and Tokio Domoto: "Demonstration of axon collateral projections from the substantia nigra pars reticulata to the superior colliculus and the parvicellular reticular formation in the rat." Brain Research. 674(1).

Yukihiko Yasui、Toshiko Tsumori、Akiro Ando 和 Tokio Domoto：“演示大鼠从黑质网状部到上丘和小细胞网状结构的轴突侧枝投射。”

Yukihiko Yasui: "Demonstration of axon collateral projections from the substantia nigra pars reticulata to the superior colliculus and the parvicellular reticular formation in the rat." Brain Research. 674. 122-126 (1995)

Yukihiko Yasui：“演示了大鼠从黑质网状部到上丘的轴突侧枝投射和小细胞网状结构。”

Yukihiko Yasui, Toshiko Tsumori, Akiro Ando, Tokio Domoto, Tetsuro Kayahara and Katsuma Nakano: "Descending projections from the superior colliculus to the reticular formation around the motor trigeminal nucleus and the parvicellular reticular formation o

Yukihiko Yasui、Toshiko Tsumori、Akiro Ando、Tokio Domoto、Tetsuro Kayahara 和 Katsuma Nakano：“从上丘到运动三叉神经核周围的网状结构和小细胞网状结构的下降投影

Yukihiko Yasui: "Descending pathways of the basal ganglia to the orofacial premotor neuron pools." In T.Morimoto et al.(Eds.), Brain and Oral Function, Elsevier, Amsterdam. 77-85 (1995)

Yukihiko Yasui：“基底神经节到口面前运动神经元池的下降通路。”

Yukihiko Yasui: "Descending pathways of the basal ganglia to the orofacial premotor neuron pools" Brain and Oral Functions : in Morimoto T et al.,eds.,Amsterdam : Elsevier. 77-85 (1995)

Yukihiko Yasui：“基底神经节到口面前运动神经元池的下降通路”《大脑和口腔功能》：森本 T 等人编辑，阿姆斯特丹：爱思唯尔。