A new search for the relationship between the amygdala and the hypothalamus

对杏仁核和下丘脑之间关系的新研究

• 批准号: 13680822
• 负责人: YASUI Yukihiko
• 金额: $ 2.24万
• 依托单位: Shimane Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13680822/
• 关键词: Amygdala; Hypothalamus; Bed nucleus of the stria terminalis; Parastrial nucleus; Endocrine response; Autonomic response; Emotional circuits; 分界条傍核; 傍条核; ラット

After combined injections of biotinylated dextranamine (BDA) into the central amygdaloid nucleus (CeA) and cholera toxin B subunit (CTb) into the paraventricular hypothalamic nucleus (PVH), good overlapping distributions of BDA-labeled axon terminals and CTb-labeled neurons were observed in the bed nucleus of the stria terminals (BST) region, mainly in the ventrolateral part of the middle BNST (BSTvl) and the parastriatal nucleus (PS). It was further revealed that the PS innervated the PV heavily, whereas the BSTvl did moderately. After CTb injection into the PS, labeled neurons were widely distributed in the forebrain region including the infralimbic cortex (IL), lateral septal nucleus (LS), shell of the accumbens nucleus (AcSh), medial preoptic area (MPA), anterior medial division of the BST (BSTam), dorsomedial hypothalamic nucleus (DMH) and central amygdaloid nucleus (Ace). Dense or moderate anterograde labeling was found in the-PS after BDA injection into the DMH or into the IL, MPA, AcSh, BSTam and Ace, respectively. These data suggest that outputs of the CeA are transmitted to the PV via the PS and the BNSTvl, and those from the limbic forebrain structures revealed here are integrated in the PS for regulating endocrine and autonomic aspects of emotional responses.

在中央杏仁核（CeA）和室旁下丘脑核（PVH）联合注射生物素化右旋胺（BDA）和霍乱毒素B亚基（CTb）后，在纹状端（BST）区床核，主要在纹状端中腹外侧部分（BSTvl）和纹状旁核（PS），观察到BDA标记的轴突终末和CTb标记的神经元有良好的重叠分布。进一步揭示了PS对PV的神经支配较重，而BSTvl对PV的神经支配较轻。经CTb注射后，标记神经元广泛分布于前脑区，包括边缘下皮层（IL）、隔外侧核（LS）、伏隔核壳（AcSh）、内侧视前区（MPA）、BST前内侧区（BSTam）、下丘脑背内侧核（DMH）和中央杏仁核（Ace）。BDA分别注射到DMH、IL、MPA、AcSh、BSTam和Ace后，在- ps中发现密集或中度的顺行标记。这些数据表明，CeA的输出通过PS和BNSTvl传递到PV，并且这些来自边缘前脑结构的输出被整合到PS中，以调节内分泌和情绪反应的自主方面。

项目成果

Ken Tsubouchi: "Forebrain afferents to the parastrial nucleus of the rat as shown by anterograde and retrograde tracing techniques"Soc. Neuroscience Abstracts. 28. 864.6 (2002)

Ken Tsubouchi：“通过顺行和逆行追踪技术显示前脑传入大鼠的旁房核”Soc。

Toshiko Tsumori et al.: "Light and electron microscopic study of the amygdalostriatonigral pathway in the rat"Acta Anatomica Nipponica. 77. 51 (2002)

Toshiko Tsumori 等人：“大鼠杏仁核纹状体黑质通路的光和电子显微镜研究”Acta Anatomica Nipponica。

Ken Tsubouchi et al.: "Indirect pathways from the central amygdaloid nucleus to the paraventricular hypothalamic nucleus in the rat."Acta Anatomica Nipponica. 76(1). 90 (2001)

Ken Tsubouchi 等人：“大鼠中从中央杏仁核到室旁下丘脑核的间接通路。”Acta Anatomica Nipponica。

Ken Tsubouchi: "Indirect pathways from the central amygdaloid nucleus to the paraventricular hypothalamic nucleus in the rat"Acta Anatomica Nipponica. 76・1. 90 (2001)

Ken Tsubouchi：“大鼠中从中央杏仁核到室旁下丘脑核的间接通路”Acta Anatomica Nipponica 76・1（2001）。

Ken Tsubouchi et al.: "Indirect pathways from the central amygdaloid nucleus to the paraventricular hypothalamic nucleus in the rat"Acta Anatomica Nipponica. 76・1. 90 (2001)

Ken Tsubouchi 等：“大鼠中从中央杏仁核到室旁下丘脑核的间接通路”Acta Anatomica Nipponica 76・1.90 (2001)。