A new search for the relationship between the amygdala and the hypothalamus

在杏仁中央核(CEA)和下丘脑室旁核(PVH)联合注射生物素化右旋糖胺(BDA)和霍乱毒素B亚单位(CTB)后，BDA标记的轴突终末和CTB标记的神经元在纹状终末床核(BST)内有良好的重叠分布，主要分布在BNST中段的腹外侧部(BSTv1)和纹状旁核(PS)。进一步揭示PS对PV的神经支配作用较强，而BSTv1对PV的神经支配作用较弱。将CTB注入PS后，标记神经元广泛分布于前脑区，包括下缘皮质(IL)、外侧隔核(LS)、伏核壳(ACSH)、内侧视前区(MPA)、BST前内侧支(BSTam)、下丘脑背内侧核(DMH)和中央杏仁核(Ace)。将BDA分别注入DMH或IL、MPA、ACSH、BSTam和Ace后，在-PS内可见密集或中度顺行标记。这些数据表明，CEA的输出通过PS和BNSTv1传递到PV，这些来自边缘前脑结构的输出被整合到PS中，以调节情绪反应的内分泌和自主神经方面。

After combined injections of biotinylated dextranamine (BDA) into the central amygdaloid nucleus (CeA) and cholera toxin B subunit (CTb) into the paraventricular hypothalamic nucleus (PVH), good overlapping distributions of BDA-labeled axon terminals and CTb-labeled neurons were observed in the bed nucleus of the stria terminals (BST) region, mainly in the ventrolateral part of the middle BNST (BSTvl) and the parastriatal nucleus (PS). It was further revealed that the PS innervated the PV heavily, whereas the BSTvl did moderately. After CTb injection into the PS, labeled neurons were widely distributed in the forebrain region including the infralimbic cortex (IL), lateral septal nucleus (LS), shell of the accumbens nucleus (AcSh), medial preoptic area (MPA), anterior medial division of the BST (BSTam), dorsomedial hypothalamic nucleus (DMH) and central amygdaloid nucleus (Ace). Dense or moderate anterograde labeling was found in the-PS after BDA injection into the DMH or into the IL, MPA, AcSh, BSTam and Ace, respectively. These data suggest that outputs of the CeA are transmitted to the PV via the PS and the BNSTvl, and those from the limbic forebrain structures revealed here are integrated in the PS for regulating endocrine and autonomic aspects of emotional responses.