Amygdaloid projections to the feeding-related neurons in the lateral hypothalamus

杏仁核投射到下丘脑外侧与进食相关的神经元

基本信息

  • 批准号:
    17500230
  • 负责人:
  • 金额:
    $ 2.18万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 财政年份:
    2005
  • 资助国家:
    日本
  • 起止时间:
    2005 至 2006
  • 项目状态:
    已结题

项目摘要

Orexin (ORX)-and melanin-concentrating hormone (MCH)-containing neurons as well as melanocortin 4 receptor (MC4-R)-expressing neurons in the lateral hypothalamus (LH) are involved in the regulation of feeding behavior. To know whether or not these neurons are under the influence of the amygdala, here we examine synaptic organization between these neurons and axon terminals originating from the central amygdaloid nucleus (CeA). MC4-R-expressing neurons were visualized as green fluorescent protein (GFP)-immunoreactive (ir) neurons using a transgenic mouse model in which GFP is produced under the control of the MC4-R promoter. After biotinylated dextran amine (BDA) injection into the CeA, overlapping distribution of BDA-labeled fibers and ORX-, MCH-, or GFP-ir neurons was seen in the LH region. In this region, BDA-labeled boutons were in contiguity with cell bodies and proximal dendrites of ORX-, MCH-, or GFP-ir neurons. Under the electron microscope, the CeA axon terminals formed asymmetrical synapses predominantly with somata and dendrites of MCH-and GFP-ir neurons, and occasionally with those of ORX-ir neurons.
下丘脑外侧部(LH)中含食欲素(ORX)和黑色素浓集激素(MCH)的神经元以及表达黑皮质素4受体(MC 4-R)的神经元参与摄食行为的调节。为了了解这些神经元是否受到杏仁核的影响,在这里,我们研究了这些神经元和起源于中央杏仁核(CeA)的轴突末梢之间的突触组织。使用转基因小鼠模型将MC 4-R表达神经元可视化为绿色荧光蛋白(GFP)免疫反应性(ir)神经元,其中GFP在MC 4-R启动子的控制下产生。生物素化葡聚糖胺(BDA)注射到CeA后,BDA标记的纤维和ORX-,MCH-,或GFP免疫反应神经元的重叠分布在LH区域。在这个区域中,BDA标记的终扣与ORX-,MCH-或GFP-免疫反应神经元的细胞体和近端树突邻接。电镜下,CeA轴突终末主要与MCH和GFP阳性神经元的胞体和树突形成不对称性突触,偶尔与ORX阳性神经元的胞体和树突形成不对称性突触。

项目成果

期刊论文数量(10)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
A light and electron microscopic analysis of the convergent insular cortical and amygdaloid projections to the posterior lateral hypothalamus in the rat, with special reference to cardiovascular function.
对大鼠下丘脑后外侧部的会聚岛叶皮质和杏仁核投射进行光学和电子显微镜分析,特别是心血管功能。
  • DOI:
  • 发表时间:
    2006
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Toyoshima Y;Onodera O;Yamada M;Tsuji S;Kozak JA;Kozak JA;Matsushita M;Michiue H;Matsushita M;Wu HY;Michiue H;Matsushita M;Wu HY;Michiue H;Noguchi H;Wu HY;Matsushita M;Arataki S;Michiue H;Fujimi K;Fujimi K;Fujimi K;Sasaki K;Noda K;Ishikawa K;Kawatake S;佐々木健介;Sasaki K;Ishikawa K;Kawatake S;佐々木健介;Noda K;Noda K;Sasaki K;Toshiko Tsumori et al.;Toshiro Kishi et al.;Toshiko Tsumori et al.
  • 通讯作者:
    Toshiko Tsumori et al.
Insular cortical and amygdaloid fibers are in contact with posterior hypothalamic neurons projecting to the nucleus of the soilitary tract in the rat.
大鼠的岛皮质和杏仁纤维与投射到尿路核的后下丘脑神经元接触。
  • DOI:
  • 发表时间:
    2006
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Toyoshima Y;Onodera O;Yamada M;Tsuji S;Kozak JA;Kozak JA;Matsushita M;Michiue H;Matsushita M;Wu HY;Michiue H;Matsushita M;Wu HY;Michiue H;Noguchi H;Wu HY;Matsushita M;Arataki S;Michiue H;Fujimi K;Fujimi K;Fujimi K;Sasaki K;Noda K;Ishikawa K;Kawatake S;佐々木健介;Sasaki K;Ishikawa K;Kawatake S;佐々木健介;Noda K;Noda K;Sasaki K;Toshiko Tsumori et al.
  • 通讯作者:
    Toshiko Tsumori et al.
Topographical projections from the hippocampal formation to the amygdala : A combined anterograde and retrograde tracing study in the rat.
从海马结构到杏仁核的地形投影:大鼠的联合顺行和逆行追踪研究。
  • DOI:
  • 发表时间:
    2006
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Toyoshima Y;Onodera O;Yamada M;Tsuji S;Kozak JA;Kozak JA;Matsushita M;Michiue H;Matsushita M;Wu HY;Michiue H;Matsushita M;Wu HY;Michiue H;Noguchi H;Wu HY;Matsushita M;Arataki S;Michiue H;Fujimi K;Fujimi K;Fujimi K;Sasaki K;Noda K;Ishikawa K;Kawatake S;佐々木健介;Sasaki K;Ishikawa K;Kawatake S;佐々木健介;Noda K;Noda K;Sasaki K;Toshiko Tsumori et al.;Toshiro Kishi et al.
  • 通讯作者:
    Toshiro Kishi et al.
Insular cortical and amygdaloid fibers are in contact with posterolateral hypothalamic neurons projecting to the nucleus of the solitary tract in the rat
  • DOI:
    10.1016/j.brainres.2005.11.040
  • 发表时间:
    2006-01
  • 期刊:
  • 影响因子:
    2.9
  • 作者:
    T. Tsumori;S. Yokota;Toshiro Kishi;Yi Qin;T. Oka;Y. Yasui
  • 通讯作者:
    T. Tsumori;S. Yokota;Toshiro Kishi;Yi Qin;T. Oka;Y. Yasui
Topographical projection from the hippocampal formation to the amygdala: A combined anterograde and retrograde tracing study in the rat
  • DOI:
    10.1002/cne.20919
  • 发表时间:
    2006-05-20
  • 期刊:
  • 影响因子:
    2.5
  • 作者:
    Kishi, T;Tsumori, T;Yasui, Y
  • 通讯作者:
    Yasui, Y
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YASUI Yukihiko其他文献

YASUI Yukihiko的其他文献

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{{ truncateString('YASUI Yukihiko', 18)}}的其他基金

Morphological analysis of the nociceptive inputs to orexin-containing neurons in the hypothalamus
下丘脑含食欲素神经元伤害性输入的形态学分析
  • 批准号:
    24500412
  • 财政年份:
    2012
  • 资助金额:
    $ 2.18万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Morphological analysis of the visceral sensory pathways to the leptin-melanocortin system in the feeding. related neural circuits of the hypothalamus
进食中瘦素-黑皮质素系统内脏感觉通路的形态学分析。
  • 批准号:
    21500325
  • 财政年份:
    2009
  • 资助金额:
    $ 2.18万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Morphological analysis of limbic modulation of leptin-melanocortin system in the feeding-related neural circuits
进食相关神经回路中瘦素-黑皮质素系统边缘调节的形态学分析
  • 批准号:
    19500294
  • 财政年份:
    2007
  • 资助金额:
    $ 2.18万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Control mechanism of midbrain dopaminergic neurons by the limbic system.
边缘系统中脑多巴胺能神经元的控制机制。
  • 批准号:
    15500238
  • 财政年份:
    2003
  • 资助金额:
    $ 2.18万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
A new search for the relationship between the amygdala and the hypothalamus
对杏仁核和下丘脑之间关系的新研究
  • 批准号:
    13680822
  • 财政年份:
    2001
  • 资助金额:
    $ 2.18万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Analysis of the lmbic neural circuits concerned with orofacial movements
与口面部运动有关的腰部神经回路分析
  • 批准号:
    11680740
  • 财政年份:
    1999
  • 资助金额:
    $ 2.18万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
The relationship between the efferents of the cortex and basal ganglia in the control of jaw movements
皮质和基底神经节传出神经控制下颌运动的关系
  • 批准号:
    08835014
  • 财政年份:
    1996
  • 资助金额:
    $ 2.18万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Morphological analysis of the neuronal circuits in the brainstem motor system
脑干运动系统神经元回路的形态学分析
  • 批准号:
    06680740
  • 财政年份:
    1994
  • 资助金额:
    $ 2.18万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (C)

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GLP-1/GLP-1R调控杏仁核参与食物渴求改善减重术后复胖的神经机制研究
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Causal contributions of deep prefrontal-amygdala circuits to social cognition
深层前额叶杏仁核回路对社会认知的因果贡献
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    MR/Y010477/1
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