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The relationship between the efferents of the cortex and basal ganglia in the control of jaw movements

皮质和基底神经节传出神经控制下颌运动的关系

基本信息

批准号：
08835014
负责人：
YASUI Yukihiko
金额：
$ 1.6万
依托单位：
Shimane Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1996
资助国家：
日本
起止时间：
1996 至 1997
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08835014/
关键词：
cerebral cortex basal ganglia substantia nigra red nucleus superior colliculus reticular formation jaw movement

项目摘要

The parvicellular reticulr formation (RFp) has been known to contain many premotor neurons for the motor trigeminal nucleus. We has already indicated that the RFp receives nigral fibers from the dorsolateral part of the substantia nigra pars reticulata (SNr) which is one of the major output nuclei of the basal ganglia, and further that the dorsolateral part of the SNr sends projection fibers to the lateralmost part of the superior colliculus (SC), where many neurons projecting to the RFp are distributed.In the present study, we first showed that the dorsolateral part of the SNr sent projection fibers to the dorsal part of the red nucleus, where many neurons projecting to the RFp existed. In this case, the nigral axon terminals made symmetrical synaptic contacts with somata and proximal dendrites of the rubral neurons sending their axons to the RFp. The dorsal part of the red nucleus has been known to receive cortical fibers from the jaw motor area.Secondly, we indicated the overlapping distributions of the cortical fibers from the jaw motor area and the tectal neurons projecting to the RFp (tecto-RFp neurons) in the lateralmost part of the SC.The cortical axons were in asymmetrical contact with dendrites of the tecto-RFp neurons. In the lateralmost part of the SC,the overlapping distributions of the nigral fibers from the dorsolateral part of the SNr and the tecto-RFp neurons were also found, as reported previously. The nigral axon terminals made symmetrical contacts with somata and dendrites of the tecto-RFp neurons. Thus, the convergent projections from the jaw motor cortex and the basal ganglia to the tectal neurons sending their axons to the RFp were revealed by the present study.

小细胞网状结构（RFp）含有许多三叉神经运动核的运动前神经元。我们已经指出，RFp接受来自黑质网状部（substantia nigra pars reticulata，SNr）背外侧部的黑质纤维，SNr是基底节的主要输出核团之一，并进一步指出，SNr的背外侧部向上级丘（superior colliculus，SC）的最外侧部发出投射纤维，那里分布着许多投射到RFp的神经元。我们首次发现，SNr的背外侧部向红核的背侧部发出投射纤维，在红核的背侧部存在许多向RFp投射的神经元。在这种情况下，黑质轴突终末与红核神经元的胞体和近端树突形成对称的突触接触，将轴突送到RFp。红核的背侧部接受来自下颌运动区的皮质纤维，在SC的近侧部，下颌运动区的皮质纤维与投射到RFp的顶盖神经元（tecto-RFp神经元）重叠分布，皮质轴突与tecto-RFp神经元的树突呈不对称接触。在SC的近外侧部，SNr背外侧部的黑质纤维和顶盖RFp神经元的重叠分布也被发现，如以前所报道的。黑质轴突终末与顶盖RFp神经元的胞体和树突对称接触。因此，本研究揭示了从下颌运动皮层和基底神经节到顶盖神经元的会聚投射，顶盖神经元将其轴突发送到RFp。