Growth prediction of jaws by using serum and urinary levels of bone metabolic markers

利用血清和尿液中骨代谢标志物水平预测颌骨生长

• 批准号: 06807159
• 负责人: SATO Koshi
• 金额: $ 1.09万
• 依托单位: TOHOKU UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06807159/
• 关键词: bone methabolic markers; late adolescence; Skeletal Class III; mandible; growth prediction; osteocalcin; PIIIP; Pyridinoline; 頭部X線規格写真; IGF-I; 成長ホルモン; 骨塩量; 下顎骨成長ポテンシャル

Growth-related changes in skeletal prognathic (Class III) craniofacial structure in late adolescence were investigated in relation to serum and urinary levels of growth factors including growth hormone (GH), insulin-like growth factor I (IGF-I), osteocalcin (OC), procollagen-III-peptide (PIIIP), pyridinoline (PYR) and Deoxypyridinoline (Dpyr).The subjects were evaluated on the basis of serial lateral cephalometric X-rays, hand bone X-rays, and serum or urinary levels of growth factors.The results were as follows :1. There was no significant difference in serum and urinary concentrations of growth factors or mean increments of craniofacial measurements between Class III and Class I subjects in late adolescence.2. There was no correlation between serum levels of growth factors and craniofacial measurements.3. The mean increments of mandibular size correlated strongly with levels of OC,PIIIP,Pyr and Dpyr.These results suggested that the levels of growth related factors were similar in patients with moderate mandibular prognathism and persons with normal occlusion. Furthermore, it was suggested that OC,PIIIP,Pyr and Dpyr were sensitive markers of the remaining amount of craniofacial growth in late adolescence.

骨颌畸形的生长相关变化本文研究了青少年晚期颅面结构与生长激素（GH）、胰岛素样生长因子I（IGF-I）、骨钙素（OC）、Ⅲ型胶原前肽（PIIIP）、吡啶啉（PYR）和脱氧吡啶啉（Dpyr）等生长因子的关系。手骨X线片及血、尿中生长因子水平。在晚期颅颌面畸形中，III类和I类受试者的血清和尿液中生长因子浓度或颅颌面测量的平均增量无显著差异.血清生长因子水平与颅面测量值无相关性.下颌骨平均生长量与OC、PIIIP、Pyr和Dpyr水平呈显著正相关，提示下颌骨中度无突患者与正常牙合患者的生长相关因子水平相似。OC、PIIIP、Pyr和Dpyr是反映青少年晚期颅面生长剩余量的敏感指标。

项目成果

佐藤亨至,他: "10代女子における尿中ピリジノリン,デオキシピリジノリンと骨量増加速度との関連について" 日本骨形態計測学会誌. 5. 179-184 (1995)

Toruji Sato 等人：“尿吡啶啉和脱氧吡啶啉与少女骨量增加率之间的关系”日本骨形态计量学会杂志 5. 179-184 (1995)。

佐藤 亨至: "10代女子における尿中ピリジノリン,デオキシピリジノリンと骨量増加速度との関連について" 日本骨形態計測学会誌. 5. 179-184 (1995)

Toruyoshi Sato：“尿吡啶啉和脱氧吡啶啉与少女骨量增加率之间的关系”日本骨形态计量学会杂志 5. 179-184 (1995)。

Koshi Sato et al: "Relationships between markers of bone resorption (pyridinoline, deoxyridinoline) and increment velocity of bone mineral density" J.Jpn. Soc. Bone Morphom. 5. 179-184 (1995)

Koshi Sato 等人：“骨吸收标志物（吡啶啉、脱氧啶啉）与骨矿物质密度增量速度之间的关系”J.Jpn。