Mechanisms of pulmonary vascular and right ventricular remodeling in heart failure with preserved ejection fraction (B09*)

射血分数保留的心力衰竭中肺血管和右心室重塑的机制 (B09*)

• 批准号: 444961147
• 金额: --
• 依托单位: Excellence Cluster Cardio-Pulmonary System (ECCPS)
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2020
• 资助国家: 德国
• 起止时间: 2019-12-31 至 2023-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/444961147?language=en
• 关键词: Mechanisms; pulmonary; vascular; right; ventricular

Pulmonary hypertension (PH) due to heart failure with preserved ejection fraction (HFpEF) is thought to be a major driver of RV remodeling. Using non-invasive daily pulmonary pressure monitoring and stress cardiac magnetic resonance imaging in addition to biventricular conductance catheter techniques, we will assess the pathophysiological mechanisms that trigger RV adaptation and maladaptive remodeling to increased left atrial pressure in HFpEF. Parallel experiments will be performed in three corresponding animal models. In addition, the effects of dapagliflozin and liraglutide on pulmonary hemodynamics and RV adaption will be investigated in a clinical registry and parallel animal experiments.

射血分数保留性心力衰竭（HFpEF）导致的肺动脉高压（PH）被认为是RV重塑的主要驱动因素。使用非侵入性每日肺动脉压监测和负荷心脏磁共振成像，除了双心室电导导管技术，我们将评估触发RV适应和适应不良重构HFpEF左心房压力增加的病理生理机制。将在三个相应的动物模型中进行平行实验。此外，将在临床登记和平行动物实验中研究达格列净和利拉鲁肽对肺血流动力学和RV适应的影响。