Evolution of rosmarinic acid biosynthesis

迷迭香酸生物合成的演变

基本信息

项目摘要

Rosmarinic acid synthase (RAS; hydroxycinnamoyl-CoA:hydroxyphenyllactate hydroxycinna-moyltransferase) is the essential enzyme for the biosynthesis of rosmarinic acid (RA) forming the ester linkage between the hydroxycinnamoyl part and the hydroxyphenyllactate moiety of the molecule. RAS should therefore be present in all rosmarinic acid (RA)-accumulating plants which can be found widely distributed throughout the plant kingdom. In lower plants, RA is present in hornworts (e.g. Anthoceros) and ferns (Blechnum). RA is moreover documented from several families of monocotyledonous and dicotyledonous angiosperms, thus being a natural compound found in a wide range of land plants. RAS from Coleus blumei (Lamiaceae) has been cloned recently and will be used as basis to isolate further RAS-genes/cDNAs from plants and express the encoded proteins for activity assays. A molecular characterization of RAS-sequences from these different plant groups and phylogenetic analyses will give indications on the evolution of RA-biosynthesis either as a monophyletic trait which has been switched off in many taxa or as an ability that has been gained several times independently.
迷迭香酸合成酶(RAS;羟基肉桂酰-CoA:羟基苯基乳酸羟基肉桂酰转移酶)是迷迭香酸(RA)生物合成的必需酶,在分子的羟基肉桂酰部分和羟基苯基乳酸部分之间形成酯键。因此,RAS应该存在于所有迷迭香酸(RA)积累中。 广泛分布于整个植物界的植物。在低等植物中,RA存在于金鱼藻(例如Anthoceros)和蕨类(Blechnum)中。此外,RA是单子叶和双子叶被子植物的几个科的记录,因此是在广泛的陆地植物中发现的天然化合物。最近从唇形科彩叶草(Coleus blumei)中克隆了RAS,并将其用作从植物中分离RAS基因/cDNA的基础,并表达编码的蛋白用于活性测定。从这些不同的植物类群和系统发育分析的RAS序列的分子表征将提供指示的RA生物合成的进化,无论是作为一个单系性状已被关闭,在许多类群或作为一种能力,已获得几次独立。

项目成果

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Professorin Dr. Maike Petersen其他文献

Professorin Dr. Maike Petersen的其他文献

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{{ truncateString('Professorin Dr. Maike Petersen', 18)}}的其他基金

Structural differences of hydroxycinnamoyl transferases in Lamiaceae - Part 1: The structure of rosmarinic acid synthase
唇形科羟基肉桂酰转移酶的结构差异 - 第 1 部分:迷迭香酸合酶的结构
  • 批准号:
    43660071
  • 财政年份:
    2007
  • 资助金额:
    --
  • 项目类别:
    Research Grants
ß-Peltatin 6-O-methyltransferase from the genus Linum: purification, cloning and expression analysis
来自亚麻属的 Λ-Peltatin 6-O-甲基转移酶:纯化、克隆和表达分析
  • 批准号:
    5409739
  • 财政年份:
    2003
  • 资助金额:
    --
  • 项目类别:
    Research Grants
Reinigung, Klonierung und Untersuchungen zur Regulation der Hydroxyphenylpyruvat Reduktase aus Coleus blumei
彩叶草羟苯基丙酮酸还原酶的纯化、克隆及调控研究
  • 批准号:
    5179728
  • 财政年份:
    1999
  • 资助金额:
    --
  • 项目类别:
    Research Grants
Metabolism of phenolic natural compounds at the threshold to life on land
陆地生命开始时酚类天然化合物的代谢
  • 批准号:
    439529174
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
    Priority Programmes

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Structural differences of hydroxycinnamoyl transferases in Lamiaceae - Part 1: The structure of rosmarinic acid synthase
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