Unravelling the impact of hepatic IL-6 resistance on macrophage programming (P09)

揭示肝脏 IL-6 耐药性对巨噬细胞编程的影响 (P09)

• 批准号: 448230686
• 金额: --
• 依托单位: Max-Planck-Institut für Stoffwechselforschung
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/448230686?language=en
• 关键词: Unravelling; impact; hepatic; IL; resistance

Chronic increased IL-6 levels in obesity lead to the development of hepatic IL-6 resistance where hepatocytes are unable to react to IL-6 signaling. Our data reveal that hepatic IL-6 resistance programs macrophages via hepatocyte-derived CSF-1 and IL-33, but the molecular consequences remain unknown. We have developed genetic mouse models to induce and prevent hepatic IL-6 resistance. Using these mice, we will investigate the impact of hepatic IL-6 resistance on macrophage programming with metabolic experiments and cell type-specific gene expression under dietary intervention.

肥胖时IL-6水平的慢性升高导致肝脏IL-6抵抗的发生，肝细胞不能对IL-6信号做出反应。我们的数据显示，肝脏IL-6抵抗通过肝细胞来源的CSF-1和IL-33编程巨噬细胞，但其分子后果尚不清楚。我们已经建立了诱导和预防肝脏IL-6抵抗的遗传性小鼠模型。利用这些小鼠，我们将通过代谢实验和饮食干预下的细胞类型特异性基因表达来研究肝脏IL-6抵抗对巨噬细胞编程的影响。