QTCC: From Quantitative Trait Correlation to Causation in dairy cattle
QTCC:从奶牛的数量性状相关性到因果关系
基本信息
- 批准号:448536632
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:德国
- 项目类别:Research Grants
- 财政年份:
- 资助国家:德国
- 起止时间:
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
The breeding goal in dairy cattle breeding includes performance traits (e.g. milk yield) and fertility and health traits, and longevity. Feed efficiency traits will be part of the breeding goal in the near future. Modern genomic tools applied to large data sets and augmented with external information about genome sequence variants allows for the comprehensive dissection of the genetic architecture of quantitative traits and, beyond that, of the shared architecture of multiple traits. The aim of the project is to analyse the interrelationships of the quantitative traits in dairy cattle beyond global correlations towards local correlation and causations. The traits considered belong to the complexes milk performance traits, fertility traits, health traits, and efficiency traits. In particular (but not exclusive), milk performance and feed efficiency will be contrasted against fertility and health traits. The following hypotheses will be tested. (i) The dissection of global genetic correlations between quantitative traits down to functional and evolutionary relevant genomic regions identifies trait-shared and trait-specific genetic architectures. (ii) The identification of pleiotropic and trait-specific lead variants allows for the separation of common and trait-specific metabolic pathways, and this in turn facilitates the identification of causative relationships between traits. (iii) Milk performance and feed efficiency are significant exposure traits which causally compromise the cow’s fertility and health. These hypotheses will be tested using modern genomic methods, partly augmented with external information, applied to a unique and disruptive observational data sets involving 150K cows with SNP-chip information, imputed whole genome sequence variants, and records for a large panel of quantitative traits. The results are important to understand and dissect the interrelationship and shared genetic architecture of the trait complexes down to single variants levels.
奶牛育种中的育种目标包括性能性状(例如产奶量)、生育力和健康性状以及寿命。饲料效率性状将是不久的将来育种目标的一部分。现代基因组工具应用于大型数据集,并增加了有关基因组序列变异的外部信息,可以全面剖析数量性状的遗传结构,除此之外,还可以剖析多个性状的共享结构。该项目的目的是分析奶牛数量性状的相互关系,超越全球相关性,走向局部相关性和因果关系。所考虑的性状属于综合的产奶性能性状、生育性状、健康性状和效率性状。特别是(但不排他),牛奶性能和饲料效率将与生育力和健康性状进行对比。将检验以下假设。(i)对数量性状到功能和进化相关基因组区域之间的全局遗传相关性的解剖确定了性状共享和性状特异性遗传结构。(ii)多效性和性状特异性先导变异的鉴定允许分离常见和性状特异性代谢途径,这反过来又有助于鉴定性状之间的因果关系。(iii)产奶性能和饲料效率是显著的暴露性状,其因果关系损害奶牛的生育力和健康。这些假设将使用现代基因组方法进行测试,部分增加了外部信息,应用于独特的和破坏性的观察数据集,涉及15万头具有SNP芯片信息的奶牛,估算的全基因组序列变异和大量数量性状的记录。这些结果对于理解和剖析性状复合体的相互关系和共享的遗传结构到单个变异水平是重要的。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Professor Dr. Jörn Bennewitz其他文献
Professor Dr. Jörn Bennewitz的其他文献
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{{ truncateString('Professor Dr. Jörn Bennewitz', 18)}}的其他基金
Structural identification of trait associated chromosomal segments and of causal mutations for quantitative traits in pooled F2 crosses using next-generation sequencing technologies and innovative statistical methods
使用新一代测序技术和创新统计方法对 F2 杂交中的性状相关染色体片段和数量性状的因果突变进行结构鉴定
- 批准号:
261898836 - 财政年份:2014
- 资助金额:
-- - 项目类别:
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Identification and functional characterization of causal genes affecting feather pecking and aggressive pecking in laying hens
影响蛋鸡啄羽和攻击性啄羽的致病基因的鉴定和功能表征
- 批准号:
202423786 - 财政年份:2011
- 资助金额:
-- - 项目类别:
Research Grants
Genomweite Analysen zur Kartierung von Genen und zur Vorhersage genomischer Zuchtwerte unter Berücksichtigung von Genoytyp-Umwelt-Interaktionen am Beispiel des Milchrindes
以奶牛为例,考虑基因型与环境的相互作用,进行全基因组分析,绘制基因图谱并预测基因组育种值
- 批准号:
157685882 - 财政年份:2010
- 资助金额:
-- - 项目类别:
Research Grants
Methodische Beiträge zur Schätzung genomischer Werte unter Berücksichtigung von Interaktionseffekten am Beispiel des Milchrindes
以奶牛为例,考虑到相互作用效应,对基因组值估计的方法学贡献
- 批准号:
97707656 - 财政年份:2009
- 资助金额:
-- - 项目类别:
Research Grants
venia legendi: Tierzucht und Haustiergenetik
venia legendi:动物育种和家畜遗传学
- 批准号:
13859913 - 财政年份:2006
- 资助金额:
-- - 项目类别:
Heisenberg Fellowships
Functional signals and hologenomic selection for P utilisation and related efficiency traits in two contrasting high-yielding laying hen strains
两种对比高产蛋鸡品系磷利用和相关效率性状的功能信号和全基因组选择
- 批准号:
386031347 - 财政年份:
- 资助金额:
-- - 项目类别:
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