a-adrenergic receptor responsiveness and baroreflex control of muscle blood flow:human and animal studies

α-肾上腺素能受体反应性和肌肉血流的压力反射控制：人类和动物研究

• 批准号: 17209007
• 负责人: NOSE Hiroshi
• 金额: $ 32.95万
• 依托单位: Shinshu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17209007/
• 关键词: EXERCISE; MUSCLE BLOOD FLOW; a-ADRENERGIC RESPONSIVENESS; BAROREFLEX SENSITIVITY; CIRCADIAN RHYTHM

[Purpose]:To assess the effects of a-adrenergic responsiveness in the vascular smooth mum/a on baroreflex control of muscle blood flow during exercise in animal and human studies.[Human studies]:1) Establishment of measurements:Determination of muscular vascular conductance: We determined the a-adrenergic responsiveness from change in forearm vascular conductance in response to such a small amount of phenylephrine injected into the brachial artery that systemic arterial pressure did not increase.Determination of baroreflex sensitivity: We determined baroreflex sensitivity from change in heart rate or muscle sympathetic nervous activity in response to spontaneous change in arterial pressure and also from change in heart rate or musk:, sympathetic nervous activity in response to a bolus injection of phenylephrine or sodium nitroprusside into the median vein.Application of doe measurements to PUTS (postural tachycardia syndrome) patients:We Sound in POTS patients that cardiac stroke volum … More e was lower during rest and exercise than in control subjects while peripheral a-adrenergic responsiveness was preserved.Effects of endurance training:We found that peripheral a-adrenergic responsiveness decreased and baroreflex sensitivity increased after endurance training in young healthy men.[Mouse studies]:We assessed baroreflex sensitivity response to acute hypovolemia in a mouse deficient of vasopressin V1a receptor and bind that cardiac baroreflex sensitivity decreased in the mouse while that increased in a control mouse.[Conclusions]These results suggest that peripheral a-adrenergic responsiveness decreased after endurance training which was accompanied by compensatory adaptation of an increase in baroreflex sensitivity. Vasopressin V1a receptors might be involved in this mechanism. However since we found that the reduced cardiac response to an upright posture in pars patients did not evoke an increase in baroreflex sensitivity, the enhanced baroreflex sensitivity might lie specifically caused by reduced a-adrenergic responsiveness in the peripheral vessels. Less

[目的]：通过动物和人体研究，探讨血管平滑肌α-肾上腺素能反应性对运动时肌肉血流压力感受性反射控制的影响。[人体研究]：1）测量的建立：肌肉血管传导性的测定：我们从前臂血管传导性的变化来测定α-肾上腺素能反应性，所述前臂血管传导性响应于注射到肱动脉中的如此少量的苯肾上腺素，使得全身动脉压不增加。我们通过心率变化或肌肉交感神经活动对动脉压自发变化的反应，心率或麝香的变化：，交感神经活动对静脉推注苯巴比妥或硝普钠的反应。在POTS（体位性心动过速综合征）患者中应用DOE测量：我们在POTS患者中发现， ...更多信息 e是较低的休息和运动比对照组，而外周α-肾上腺素能反应性是preserved.Effects的耐力training：我们发现，外周α-肾上腺素能反应性下降，压力反射敏感性增加耐力训练后，在年轻的健康男性。[小鼠研究]：我们评估了加压素V1 a受体缺陷小鼠对急性低血容量的压力反射敏感性反应，并发现小鼠心脏压力反射敏感性降低，而对照小鼠心脏压力反射敏感性增加。[结论]耐力训练后外周α-肾上腺素能反应性降低，同时伴随着压力反射敏感性增加的代偿性适应。加压素V1 a受体可能参与了这一机制。然而，由于我们发现，减少心脏反应，以直立姿势在pars患者并没有引起压力反射敏感性的增加，压力反射敏感性的增强可能是特别是由减少外周血管中的α-肾上腺素能反应性。少

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ITでどこまでわかるか?

我们对IT能了解多少？

• 发表时间: 2007
• 期刊: 肥満と糖尿病 6
• 作者: 能勢 博;他
• 通讯作者: 他

Improved cutaneous vasodilation and blunted hyperosmotic suppression sensitivity after endurance training in humans

人类耐力训练后改善皮肤血管舒张并减弱高渗抑制敏感性

• 发表时间: 2005
• 期刊: J. Appl. Physiol. 99
• 作者: Ichinose T;K. Okazaki;S. Masuki;H. Mitono;M. Chen;H. Endoh;and H. Nose
• 通讯作者: and H. Nose

Transient cutaneous vasodilation and hypotension after drinking in dehydrated and exercising men

脱水和运动的男性饮酒后出现短暂的皮肤血管舒张和低血压

• 发表时间: 2005
• 期刊: J. Physiol(Lond) 568
• 作者: Kamijo;Y.;et. al.
• 通讯作者: et. al.

Ten-day endurance training attenuates the hyperosmotic suppression of cutaneous vasodilation during exercise but not sweating.

十天的耐力训练会减弱运动过程中皮肤血管舒张的高渗抑制，但不会减弱出汗。

• 发表时间: 2005
• 期刊: Journal of Applied Physiology 99
• 作者: Tsukahara;S;Ikeda;R;Goto;S;Yoshida;K;Mitsumori;R;Sakamoto;Y;Tajima;A;Yokoyama;T;Toh;S;Furukawa;K;Inoue;I;渡辺 恵,川原茂敬;T.Ichinose et al.
• 通讯作者: T.Ichinose et al.

信州から世界へ!「インターバル速歩の現状と将来」

从信州走向世界！“间歇跑的现状与未来”

• 发表时间: 2008
• 作者: Iwasawa T;Iwasaki K;Sawada T;Okada A;Ueyama K;Motomura S;Harata S;Inoue I;Toh S;Furukawa;能勢 博
• 通讯作者: 能勢 博